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Investigation about the effect of Adrenomedullin on pulmonary function and development of emphysema of old mice

Investigation about the effect of Adrenomedullin on pulmonary function and development of emphysema of old mice
肾上腺髓质素对老年小鼠肺功能及肺气肿发生影响的研究
批准号：
22590835
负责人：
YAMAMOTO Hiroshi
金额：
$2.75万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2012
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590835/
关键词：
閉塞性肺疾患アドレノメデュリン

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英文摘要
We investigated pulmonary function and histological changes of old or young AM-KO mice correspondent with its littermate control. RV and RV/TLC of old mice were significantly increased compared with that of young mice. Mean linear intercept (Lm) of old mice was significantly increased than that of young mice. Mean alveolar area and destructive index (DI) were not significantly increased. AM gene modification did not have any effect on these indexes.
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