Investigation about the effect of Adrenomedullin on pulmonary function and development of emphysema of old mice

肾上腺髓质素对老年小鼠肺功能及肺气肿发生影响的研究

• 批准号: 22590835
• 负责人: YAMAMOTO Hiroshi
• 金额: $ 2.75万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590835/
• 关键词: 閉塞性肺疾患; アドレノメデュリン

We investigated pulmonary function and histological changes of old or young AM-KO mice correspondent with its littermate control. RV and RV/TLC of old mice were significantly increased compared with that of young mice. Mean linear intercept (Lm) of old mice was significantly increased than that of young mice. Mean alveolar area and destructive index (DI) were not significantly increased. AM gene modification did not have any effect on these indexes.

本研究观察了老龄和幼龄AM-KO小鼠肺功能和肺组织学变化，并与同窝对照组进行比较。老年小鼠RV和RV/TLC明显高于青年小鼠。老年小鼠的平均线性截距（Lm）显著高于青年小鼠。平均肺泡面积和破坏指数（DI）没有显著增加。AM基因修饰对上述指标无影响。