Study on mechanism of tissue degradation by membrane-type matrix metalloproteinase

膜型基质金属蛋白酶降解组织的机制研究

• 批准号: 19390084
• 负责人: SATO Hiroshi
• 金额: $ 11.98万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390084/
• 关键词: MT1-MMP; 組織破壊; MMP-2; GDF-15; 細胞接着斑; ERK; 細胞運動; 分子標的; GDF15; TIMP-2; 活性化; p53; p21

膜型マトリックスメタロプロテアーゼー1(MT1-MMP)の機能は、潜在型MMP-2の活性化と基質切断の2つに大別できる。人工的MMP-2受容体MSP-TIMP-2を考案してMMP-2活性化機構の解明とMMP-2活性化の生理的意義を明らかにした。また、MT1-MMP新規基質を同定し、がん浸潤・転移に果たす役割を解明した。さらにMT1-MMPの細胞接着斑における機能を解析し、細胞運動なに果たす役割を解明した。

The membrane type device is used to improve the mechanical performance of the film type 1 (MT1-MMP), and the latent type of MMP-2 is activated to cut off the substrate for the second time. The artificial MMP-2 receptor MSP-TIMP-2 test shows that the MMP-2 activation mechanism can understand the physiological meaning of MMP-2 activation. The basis of the new rules and regulations of MT1-MMP is the same as that of the new rules, and the results of the new rules of the new regulations are similar to those of the new regulations of the United States. In the MT1-MMP system, the machine is used to analyze and analyze the results of the operation.

项目成果

Cleavage of growth differentiation factor 15 (GDF15) by membrane type 1-matrix metalloproteinase abrogates GDF15-mediated suppression of tumor cell growth

• DOI: 10.1111/j.1349-7006.2007.00547.x
• 发表时间: 2007-09-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: El-Aziz, Shaban H. Abd;Endo, Yoshio;Sato, Hiroshi
• 通讯作者: Sato, Hiroshi

N-cadherin- based cell-cell interactlon by JSAP1 scaffold in PC12h cells.

PC12h 细胞中 JSAP1 支架基于 N-钙粘蛋白的细胞间相互作用。

• 发表时间: 2007
• 期刊: Biochem. Biophys. Res. Commun. 353
• 作者: Sakatani;S.;et al.;Munkhuu Bayarsaikhan
• 通讯作者: Munkhuu Bayarsaikhan

MT1-MMPはERKを介して細胞増殖と浸潤を増強する

MT1-MMP 通过 ERK 增强细胞增殖和侵袭

• 发表时间: 2008
• 作者: 滝野隆久;佐藤博
• 通讯作者: 佐藤博

Phosphorylation of extracellular signal-regulated kinase 1/2, p^<38> mitogen-activated protein kinase and nuclear translocation of nuclear factor-kappaB are involved in upregulation of matrix metalloproteinase-9 by tumour necrosis factor-alpha

细胞外信号调节激酶1/2、p^38丝裂原激活蛋白激酶的磷酸化和核因子-κB的核转位参与肿瘤坏死因子-α对基质金属蛋白酶-9的上调

• 发表时间: 2008
• 期刊: Liver Int. 29
• 作者: Itatsu K;Sasaki M;Harada K;Yamaguchi J;Ikeda H;Sato Y;Ohta T;Sato H;Nagino M;Nimura Y;Nakanuma Y.
• 通讯作者: Nakanuma Y.

細胞接着斑におけるMT1-MMPの役割

MT1-MMP 在细胞粘附焦点中的作用

• 发表时间: 2007
• 作者: 滝野隆久;佐藤 博
• 通讯作者: 佐藤 博