Roles of obesity and dietary factors on multistage carcinogenesis and risk assessment

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Estimates suggest that 35% of all human cancers have a linkage to dietary and obesity. Several reports showed the evidences of an association between obesity and cancer derives from cohort studies. To clarify the roles of obesity and dietary factors on multistage carcinogenesis and risk assessment, we examined DNA damage and ability for cell proliferation for chlorogenic acid, 2-nitrotoluene, phthalate and status of high glucose and oxidative stress. These factors could cause DNA damage and gene expression under several conditions, and therefore further studies are needed to prevent cancers due to dietary factors and obesity.