Molecular epidemiology of nasopharyngeal carcinoma in southern Chinaand searching for early detection biomarkers
Molecular epidemiology of nasopharyngeal carcinoma in southern Chinaand searching for early detection biomarkers
批准号:
22406016
负责人:
MURATA Mariko
金额:
$12.31万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Epstein-Barr virus-associated nasopharyngeal carcinoma (NPC) is endemic in southern China. Questionnaire investigation suggested significant association between NPC and environmental factors such as smoking and foods. Strongimmunnoreactivities of 8-oxodG and 8-nitroguanine were observed in the cancer cells of NPC patients. The difference in the serum levels of 8-oxodG between the NPC patients and controls showed statistically significant, suggesting that 8-nitroguanine and 8-oxodG could be potential biomarkers for evaluating the risk of NPC. We revealed the epigenetic inactivation of several genes by promoter hypermethylation in NPC.
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Epigenetic inactivation of paracrined-FSTL1 modulates macrophage functions in nasopharyngeal carcinoma
旁分泌-FSTL1的表观遗传失活调节鼻咽癌中的巨噬细胞功能
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Xiao Xue]
通讯作者:
Xiao Xue
Frequent inactivation of FSTL1 by promoter hypermethylation in nasopharyngeal carcinomas
鼻咽癌中启动子高甲基化频繁导致 FSTL1 失活
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Xue Xiao, et al]
通讯作者:
et al
TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma.
TFPI-2 是一种推定的肿瘤抑制基因,在鼻咽癌中经常因启动子高甲基化而失活
DOI:
10.1186/1471-2407-10-617
发表时间:
2010-11-09
期刊:
BMC cancer
影响因子:
3.8
作者:
[Wang S, Xiao X, Zhou X, Huang T, Du C, Yu N, Mo Y, Lin L, Zhang J, Ma N, Murata M, Huang G, Zhang Z]
通讯作者:
Zhang Z
多層カーボンナノチューブによる細胞内DNA損傷の解析(第2報) 繊維長の影響
多壁碳纳米管引起的细胞内DNA损伤分析(第二报告)纤维长度的影响
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[田中大祐, 小泉昭夫, 稲垣暢也, 他, 平工雄介]
通讯作者:
平工雄介
RRAD with tumor suppressive function is aberrantly methylated innasopharyngeal carcinoma
具有抑癌功能的RRAD在鼻咽癌中异常甲基化
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Yingxi Mo, Kaoru Midorikawa, Zhe Zhang, Xiaoying Zhou, Guangwu Huang, Ning Ma, Yusuke Hirakul, Shinji Oikawa, Mariko Murata]
通讯作者:
Mariko Murata
共 81 条
Can a dietary factor taurine suppress carcinogenesis?
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批准号:19K22757
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Molecular mechanism of infection/inflammation-associatedcarcinogenesis and cancer prevention
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批准号:22390121
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资助金额:$12.73万
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财政年份:2010
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Molecular epidemiology study on carcinogenic mechanism of Epstein-Barr-associated nasopharyngeal carcinoma and modification by environmental factors in southern China
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批准号:19406021
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项目类别:Grant-in-Aid for Scientific Research (B)
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依托单位:
Roles of obesity and dietary factors on multistage carcinogenesis and risk assessment
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批准号:19390161
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财政年份:2007
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Mechanism of carcinogenesis in female reproductive organs induced by environmental estrogens
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负责人:MURATA Mariko
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依托单位:
Analysis of the human DNA damage by dietary factors via reactive oxygen species and cancer prevention
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批准号:12670318
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资助金额:$1.92万
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财政年份:2000
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负责人:MURATA Mariko
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Analysis of the human DNA damageby antioxidants for evaluation of safety in cancer chemoprevention
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批准号:09670356
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资助金额:$1.92万
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财政年份:1997
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负责人:MURATA Mariko
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依托单位:
Clinical study of postnatal depression. -The impact on child development-
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批准号:06670958
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项目类别:Grant-in-Aid for Scientific Research (C)
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财政年份:1994
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负责人:MURATA Mariko
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依托单位:
海外基金