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Molecular epidemiology of nasopharyngeal carcinoma in southern Chinaand searching for early detection biomarkers

Molecular epidemiology of nasopharyngeal carcinoma in southern Chinaand searching for early detection biomarkers
中国南方鼻咽癌分子流行病学及早期检测生物标志物的寻找
批准号:
22406016
负责人:
MURATA Mariko
金额:
$12.31万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
Epstein-Barr virus-associated nasopharyngeal carcinoma (NPC) is endemic in southern China. Questionnaire investigation suggested significant association between NPC and environmental factors such as smoking and foods. Strongimmunnoreactivities of 8-oxodG and 8-nitroguanine were observed in the cancer cells of NPC patients. The difference in the serum levels of 8-oxodG between the NPC patients and controls showed statistically significant, suggesting that 8-nitroguanine and 8-oxodG could be potential biomarkers for evaluating the risk of NPC. We revealed the epigenetic inactivation of several genes by promoter hypermethylation in NPC.
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会议论文
Epigenetic inactivation of paracrined-FSTL1 modulates macrophage functions in nasopharyngeal carcinoma
旁分泌-FSTL1的表观遗传失活调节鼻咽癌中的巨噬细胞功能
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Xiao Xue]
通讯作者: Xiao Xue
Frequent inactivation of FSTL1 by promoter hypermethylation in nasopharyngeal carcinomas
鼻咽癌中启动子高甲基化频繁导致 FSTL1 失活
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Xue Xiao, et al]
通讯作者: et al
TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma.
TFPI-2 是一种推定的肿瘤抑制基因,在鼻咽癌中经常因启动子高甲基化而失活
DOI: 10.1186/1471-2407-10-617
发表时间: 2010-11-09
期刊: BMC cancer
影响因子: 3.8
作者: [Wang S, Xiao X, Zhou X, Huang T, Du C, Yu N, Mo Y, Lin L, Zhang J, Ma N, Murata M, Huang G, Zhang Z]
通讯作者: Zhang Z
多層カーボンナノチューブによる細胞内DNA損傷の解析(第2報) 繊維長の影響
多壁碳纳米管引起的细胞内DNA损伤分析(第二报告)纤维长度的影响
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [田中大祐, 小泉昭夫, 稲垣暢也, 他, 平工雄介]
通讯作者: 平工雄介
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