Molecular mechanism of infection/inflammation-associatedcarcinogenesis and cancer prevention

感染/炎症相关致癌和癌症预防的分子机制

• 批准号: 22390121
• 负责人: MURATA Mariko
• 金额: $ 12.73万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390121/
• 关键词: 炎症; 発がん; 活性酸素・窒素; 8-ニトログアニン; 幹細胞; 感染症; 慢性炎症; 発がん機構; DNA損傷; 活性酸素; カーボンナノチューブ; エンドサイトーシス; 代謝酵素; エピゲノム異常

Chronic inflammation induced by biological, chemical, and physical factors has been found to be associated with the increased risk of cancer. We revealed that the nuclear localization of COX-2, which was reported to function as a transcription factor, was significantly associated with the up-regulation of stem cell marker in cancer tissues with parasite infection. COX-2 activation may be involved in stem cell proliferation/differentiation in inflammation-mediated carcinogenesis. 8-Nitroguanine was formed in stem cell marker-positive cells in inflammation-associated cancer tissues. Inflammation may increase the number of mutant stem cells, in which iNOS-dependent DNA damage occurs via NF-κB activation, leading to tumor development.

发现由生物学，化学和物理因素引起的慢性炎症与癌症风险增加有关。我们透露，据报道，COX-2的核定位置与寄生虫感染的癌症组织中干细胞标记物的上调显着相关。 COX-2激活可能与炎症介导的致癌作用中的干细胞增殖/分化有关。在炎症相关的癌症组织中，在干细胞标记阳性细胞中形成8-硝基瓜。炎症可能会增加突变干细胞的数量，其中iNOS依赖性DNA损伤通过NF-κB激活导致肿瘤发育。

项目成果

Nitrative DNA damage induced by multi-walled carbon nanotube in cultured cells: a comparison with oxidative DNA damag

多壁碳纳米管在培养细胞中诱导的硝基 DNA 损伤：与氧化 DNA 损伤的比较

• 发表时间: 2013
• 作者: Tanaka E;Yatsuya H;Uemura M;Murata C;Otsuka R;Toyoshima H;Tamakoshi K;Sasaki S;Kawaguchi L;Aoyama A;Feiye Guo
• 通讯作者: Feiye Guo

Up-regulation of GLRX3 is associated with invasion and metastasis in nasopharyngeal carcinoma

GLRX3的上调与鼻咽癌的侵袭和转移相关

• 发表时间: 2013
• 作者: Bo Hou;他
• 通讯作者: 他

Tumor microenvironment & Oncogenesis", Formation of 8-nitroguanine, a DNA lesion associated with inflammation-related carcinogenesis, in human lung in relation to asbestos exposure

肿瘤微环境

• 发表时间: 2010
• 作者: Hiraku Y;Sakai K;Shibata E;Kamijima M;Hisanaga N;Ma N;Kawanishi S;Murata M
• 通讯作者: Murata M

多層カーボンナノチューブで処理したヒト肺上皮細胞におけるニトロ化DNA損傷

多壁碳纳米管处理人肺上皮细胞的硝化 DNA 损伤

• 发表时间: 2011
• 作者: Feiye Guo;馬寧;川西正祐;村田真理子;平工雄介
• 通讯作者: 平工雄介

Protective effect of melatonin against Opisthorchis viverrini-induced oxidative and nitrosative DNA damage and liver injury in hamsters

• DOI: 10.1111/j.1600-079x.2010.00792.x
• 发表时间: 2010-10-01
• 期刊: JOURNAL OF PINEAL RESEARCH
• 影响因子: 10.3
• 作者: Laothong, Umawadee;Pinlaor, Porntip;Pinlaor, Somchai
• 通讯作者: Pinlaor, Somchai