Molecular mechanism of infection/inflammation-associatedcarcinogenesis and cancer prevention

点击翻译按钮获取中文摘要

Chronic inflammation induced by biological, chemical, and physical factors has been found to be associated with the increased risk of cancer. We revealed that the nuclear localization of COX-2, which was reported to function as a transcription factor, was significantly associated with the up-regulation of stem cell marker in cancer tissues with parasite infection. COX-2 activation may be involved in stem cell proliferation/differentiation in inflammation-mediated carcinogenesis. 8-Nitroguanine was formed in stem cell marker-positive cells in inflammation-associated cancer tissues. Inflammation may increase the number of mutant stem cells, in which iNOS-dependent DNA damage occurs via NF-κB activation, leading to tumor development.