Roles of microRNA in inflammation-related carcinogenesis and its possibility for use as a biomarker

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Epstein-Barr virus-associated nasopharyngeal carcinoma (NPC) is one of the inflammation-associated cancers. To explore the mechanisms of NPC development and certain biomarkers for screening, a microarray profiling survey was performed to reveal the expression patterns of microRNAs across primary tumors (NPC) and normal nasopharyngeal epithelia (NNE). Quantitative real-time PCR confirmed that expression levels of the microRNAs were significantly different between NPC and NNE tissues. Several microRNAs also have significant differences in plasma samples. Up- and down-regulated microRNAs may play a role in NPC development and there is a possibility to use as biomarkers and novel targets for NPC treatment.