Iung repair by lung endogenous stem cells

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We established a method to isolate lung endogenous stem cells from human and murine lungs. These stem cells had differential potentials into multi-lineage. At the same time, they had an alveolar epithelial phenotype. In murine elastase-induced lung injury model, administration of lung endogenous stem cells attenuated the injury and improved the survival ratio, suggesting a potential cell therapy to lung diseases. In addition, lung endogenous stem cells, which have a potential to differentiate into alveolar epithelium, have been discovered from adult human lungs for the first time. These cells are useful for a drug discovery.