Molecular biological analysis of intratumoral inhomogeneous radiosensitivity

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Tumors of human origin with wild-type (wt) p53 or mutant-type (mt) p53 were transplanted to nude mice and irradiated with carbon ion beams or X-rays to analyze intratumoral inhomogeneous radiosensitivity. In wt-p53 tumors, apoptosis increased after low dose irradiation and significant changes in gene expression were found. Little difference between the profiles induced by carbon ion and those by X-rays was shown, but the two types of tumor cells in a tumor showed different profiles. In mt-p53 tumors, significant changes in gene expression were shown after high dose irradiation, but the profiles induced by carbon ion and those by X-rays were different.