The expression and function of microRNA in esophageal cancer cells and normal esophageal epithelial cells
The expression and function of microRNA in esophageal cancer cells and normal esophageal epithelial cells
批准号:
19390356
负责人:
SHIMADA Yutaka
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
正常食道上皮で発現が見られないPolo-like kinase 1 (PLK1)が食道扁平上皮癌細胞株11株で発現しており、このPLK1をターゲットとするmiR-593*を同定した。一方、Barrett腺癌ではmiR-106b-25クラスターが高発現しており、miRs -93 と -106b のターゲットはp21で、miR-25 のターゲットはBimと考えられた。以上の事から食道扁平上皮癌ではmiR-593*が、腺癌ではmiR-106b-25クラスターが食道癌における有力な分子標的となりうるものと考えられた。
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Polo-like kinase 1の食道癌細胞増殖能に於ける役割とmicroRNA-593*による転写後制御
Polo 样激酶 1 在食管癌细胞增殖能力中的作用以及 microRNA-593* 的转录后调控
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[佐藤史顕, 土屋創建, 嶋田裕, 清水一治]
通讯作者:
清水一治
Downregulation of PTTG1 by SiRNA supress cell proliferation of esophageal squamous cell carcinoma
SiRNA下调PTTG1抑制食管鳞癌细胞增殖
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Ito T, Shimada Y, et.al.]
通讯作者:
et.al.
Significance of Karyopherin alfa 2 (KPNA2) expression in esophageal squamous cell carcinoma
核转运蛋白α2(KPNA2)在食管鳞癌中表达的意义
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Shimada Y, et.al.]
通讯作者:
et.al.
Role of Fascin in anoikis and tumor formation in esophageal squamous cell carcinoma (ESCC).
Fascin 在失巢凋亡和食管鳞状细胞癌 (ESCC) 肿瘤形成中的作用。
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Ortiz C, Shimada Y, et.al.]
通讯作者:
et.al.
DOI:
10.1159/000136156
发表时间:
2007-01-01
期刊:
ONCOLOGY
影响因子:
3.5
作者:
[Ito, Tetsuo, Tanaka, Eiji, Shimada, Yutaka]
通讯作者:
Shimada, Yutaka
共 19 条
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