Optimization of bone substitutes in dental field

牙科领域骨替代品的优化

• 批准号: 19390513
• 负责人: KASUGAI Shohei
• 金额: $ 12.31万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390513/
• 关键词: 骨補填材; ハイドロキシアパタイト; TCP; シンバスタチン; 骨; 骨再生; 骨造成; 再生; α-TCP; スタチン; BMP

Various calcium phosphate materials of different forms, which are resorbable or not resorbable, have been used as bone substitutes. However, autologous bone graft is still a gold standard for bone augmentation. Although bone substitutes, which are currently available, function as scaffold for bone regeneration and although they are osteo-conductive, they do not stimulate bone formation. The purpose of this project is to develop bone substitutes, which exchange to real bone stimulating bone formation. Firstly, we developed hydroxyapatite (HA) fiber material of 15μm diameter and demonstrated that this material exchanges to bone without inhibiting bone regeneration in animal experiments. Secondary, we developed the bone substitute by combining α-TCP, which is resorbable material, and simvastatin, which is an inhibitor of cholesterol synthesis. We observed that this bone substitute stimulates bone formation and exchanges to bone in animal experiments. Furthermore, efficacy and safety of this bone substitute were confirmed in clinical study. The two bone substitutes, which were developed in this project, would be potentially effective in dental field compared to the ones, which are clinically used.

可吸收或不可吸收的不同形式的各种磷酸钙材料已被用作骨替代物。然而，自体骨移植仍然是骨增量的金标准。尽管目前可用的骨替代物用作骨再生的支架，尽管它们是骨传导的，但它们不刺激骨形成。本项目的目的是开发骨替代物，将其转换为真实的骨，刺激骨形成。首先，我们研制了直径为15μm的羟基磷灰石（HA）纤维材料，并在动物实验中证明该材料可与骨交换而不抑制骨再生。其次，我们将可吸收材料α-TCP与胆固醇合成抑制剂辛伐他汀结合，研制成骨替代材料。我们在动物实验中观察到这种骨替代物刺激骨形成和骨交换。此外，该骨替代物的有效性和安全性在临床研究中得到证实。与临床使用的骨替代物相比，本项目开发的两种骨替代物在牙科领域具有潜在的有效性。

项目成果

Effects of prostaglandin El application on rat incisal sockets.

前列腺素El应用对大鼠切牙槽的影响。

• 发表时间: 2008
• 期刊: International Journal of Oral Maxillofacial Implants 23(5)
• 作者: lino G;Hishimura K;Omura K;Kasugai S.
• 通讯作者: Kasugai S.

Effects of Vascular endothelial growth factor (VEGF) on neovascularization and osteogenesis in areas of poor blood supply : histological study on the rabbit skulls

血管内皮生长因子（VEGF）对血液供应不良区域新生血管和成骨的影响：兔头骨的组织学研究

• 发表时间: 2007
• 期刊: Journal of Oral Tissue Engineering 5(2)
• 作者: Sakuyama A;Shiota M;Fujimori T;Yamashita Y;Kasugai S.
• 通讯作者: Kasugai S.

Effects of simvastatin and alpha-tricalcium phosphate combination on the early healing of bone defects

辛伐他汀联合α-磷酸三钙对骨缺损早期愈合的影响

• 发表时间: 2009
• 作者: Nyan M;Machida T;Noritake K;Miyahara T;Kuroda S;Kasugai S.
• 通讯作者: Kasugai S.

骨形形成を促進する化合物を含む吸収性骨補填材

含有促进骨形成的化合物的可吸收骨替代材料

• 发表时间: 2008
• 作者: Ueno N;Sato D;Nyan M;KondoH;Kasugai.;Kasugai S.;春日井昇平
• 通讯作者: 春日井昇平

Particle size effect on augmented bone volume in autologous graft

粒径对自体移植骨量增加的影响

• 发表时间: 2008
• 作者: Kon K;Shiota M;Ozeki M;Kimura J;Kasugai S.
• 通讯作者: Kasugai S.