Optimization of bone substitutes in dental field

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Various calcium phosphate materials of different forms, which are resorbable or not resorbable, have been used as bone substitutes. However, autologous bone graft is still a gold standard for bone augmentation. Although bone substitutes, which are currently available, function as scaffold for bone regeneration and although they are osteo-conductive, they do not stimulate bone formation. The purpose of this project is to develop bone substitutes, which exchange to real bone stimulating bone formation. Firstly, we developed hydroxyapatite (HA) fiber material of 15μm diameter and demonstrated that this material exchanges to bone without inhibiting bone regeneration in animal experiments. Secondary, we developed the bone substitute by combining α-TCP, which is resorbable material, and simvastatin, which is an inhibitor of cholesterol synthesis. We observed that this bone substitute stimulates bone formation and exchanges to bone in animal experiments. Furthermore, efficacy and safety of this bone substitute were confirmed in clinical study. The two bone substitutes, which were developed in this project, would be potentially effective in dental field compared to the ones, which are clinically used.