Acceleration of atherosclerosis by periodontopathic bacteria and development of preventive vaccine

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Periodontopathic bacteria accelerated atherosclerosis with an increase in atherogenic factors such as serum CRP and LPS, bacterial DNA, and inflammatory risk factors such as IL-6, IL-8, TNF・, MCP-1, TLR2, TLR4, ICAM-1, E-selectin, P-selectin, LOX-1, HSP60, CCL19, CCL21, and CCR7 in Apoe-deficient mice, which suggests that the inflammatory proceess caused by periodontopathic bacteria aggravates the atherosclerosis. In addition, antioxidant and vaccine treatments controlled the development of atherosclerosis comes from these inflammations, may be a useful tool for prevention and treatment of atherosclerotic vascular diseases.