Elucidation of autoummune condition in periodontitis-accelerated atherosclerosis and control by oral tolerance

除了活菌外，细胞成分如LPS也参与了牙周病菌加速动脉粥样硬化的过程，影响了TLR、MLR和氧化应激（HSP）的表达。牙周感染引起的自身抗原的增加是TLR依赖性的，并与临床样本中自身抗体的增加相关。此外，研究表明牙周病细菌对LDL的氧化修饰可引起自身免疫性疾病。相比之下，接种牙龈卟啉单胞菌可通过降低炎症标志物和自身免疫标志物来抑制动脉粥样硬化。这些结果提示口服耐受性诱导对减少动脉硬化是有效的。

Not only live bacteria but also the cellular components, such as LPS have been participated in acceleration of the atherosclerosis by periodontopathic bacteria,and affected expression of TLR,MLR and oxidant stress,or HSP. The increase in autoantigens by periodontal infection was TLR dependent and correlated with the increase in autoantibody in clinical samples.Furthermore, it was suggested that oxidative modefication of LDL by periodontopathic bacteria induced autoimmune disorder.In contrast, immunization with P.gingivalis GroEL suppressed atherosclerosis with the reduction of inflammatory markers and autoimmune markers. These results suggest that oral tolerance induction is effective in reducing arteriosclerosis.