Health effect evaluation based on characteristics of nanoparticles

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This experiment was conducted to clarify the appropriate assessment for health effect based on the nanoparticles characteristics with emphasis on neurological effects. 1. Nanopariticles incorporated into the olfactory bulb and brain tissue is highly relevant astrocytes and micoglia cells rather than neurons. Nanoparticles may be immediately taken up by phagocyte cells and clearance in the local. Therefore, the safety evaluation of nanoparticles is necessary to examine in the olfactory bulb and/or brain as well as the heart and lung. 2. The pharmacokinetics of nanoparticles may be affected by the chemical characteristics and the physical properties. 3. The safety evaluation of nanomaterials needs to test fully the toxicity on organ metabolism in vivo experiment. In conclusion, the health assessment of nanoparticles must be evaluated by both in vitro and in vivo studies based on its chemical and physical characteristics, and requiring the establishment of a new test methods including evaluation of toxicity in the nerve tissues.