Study of nanomaterials on chronic health effect assessment according to endpoint of carcinogenesis and lung fibrosis

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Experiments were conducted to evaluate properly the chronic effect of nano-materials in vivo and in vitro. Results of cytotoxicity, proliferative activity, mutagenicity and transformation were affected by the physical-chemical properties of test materials in vitro. The risk assessment at concentration of 0.1μg-1mg was performed at the single-dose of tracheal injection in normal animals, and the progress of fibrosis and oncogenesis were observed during 1.6 year in normal animals. Appropriated animal experiment was performed without using genetically modified animals. There were divergence results between in vitro and in vivo experiments.The research results should be carefully applied to human risk assessment.