Study of regulation mechanisms in the cell cycle coordinated with cell differentiation with translucent blastomeres of the frog, Xenopus laevis

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We studied the molecular mechanisms in cell cycle and cell differentiation with the efficient bio-imaging system of the translucent blastomeres of the frog, Xenopus laevis. The interactions of molecules necessary for DNA synthesis, such as DNA polymerase and cdc 45, was clarified with FRET methods. we found that the decrease in protein synthesis during MBT determined the onset of cell cycle elongation followed by cell differentiation. In addition, we investigated the role of Ca ions in the regulation of cell cycle and cell differentiation during early embryonic development.