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Elucidation of the molecular evolution of the major histocompatibility complex (MHC) molecule, critical for the defense system of the jawed vertebrates

Elucidation of the molecular evolution of the major histocompatibility complex (MHC) molecule, critical for the defense system of the jawed vertebrates
阐明对有颌脊椎动物的防御系统至关重要的主要组织相容性复合体 (MHC) 分子的分子进化
批准号:
19570223
负责人:
HASHIMOTO Keiichiro
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2010

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中文摘要
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英文摘要
To elucidate the evolution of MHC molecules in the vertebrates, we tried to isolate novel MHC-related genes from various fish genome. Fish is the critical and the most primitive animal group in which the MHC-related genes could be found. We investigated MHC-related genes in the fish genome and also transcripts of those genes using RACE method. We also found some genes in the fish which can encode proteins with some MHC-related domains.
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会议论文
MHC class Ib分子MR1の細胞内相互作用分子の解析
MHC Ib类分子MR1的胞内相互作用分子分析
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Dijkstra, J. M., 山口央輝]
通讯作者: 山口央輝
Evolution of cytokines important for T helper cell differentiation.
对 T 辅助细胞分化很重要的细胞因子的进化。
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Dijkstra JM, Ohtani M, Hayashi N, Nakanishi T, Hashimoto K.]
通讯作者: Hashimoto K.
DOI: 10.1007/s00251-010-0460-1
发表时间: 2010-08-01
期刊: IMMUNOGENETICS
影响因子: 3.2
作者: [Ohashi, Ken, Takizawa, Fumio, Dijkstra, Johannes Martinus]
通讯作者: Dijkstra, Johannes Martinus
Evolution of cytokines important for Thelper cell differentiation
对 Thelper 细胞分化很重要的细胞因子的进化
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Dijkstra JM, Ohtani M, Hayashi N, Nakanishi T, Hashimoto K., Dijkstra JM]
通讯作者: Dijkstra JM
23
    Elucidation of the molecular evolution of MHC family and the establishment of the acquired immune system
    • 批准号:
      15590443
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.98万
    • 财政年份:
      2003
    • 负责人:
      HASHIMOTO Keiichiro
    • 依托单位:
    Studies on the molecular evolution of MHC class I genes and their polymorphism
    • 批准号:
      13670324
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2001
    • 负责人:
      HASHIMOTO Keiichiro
    • 依托单位:
    Studies on the molecular evolution of MHC class I genes and their polymorphism
    • 批准号:
      11670330
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      1999
    • 负责人:
      HASHIMOTO Keiichiro
    • 依托单位:
    Studies on the molecular evolution of MHC class I genes and their polymorplusin
    • 批准号:
      09670346
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.92万
    • 财政年份:
      1997
    • 负责人:
      HASHIMOTO Keiichiro
    • 依托单位:
    海外基金