CONSTRUCTION OF POLYCYCLIC SYSTEMS USING OXIDATION OF AROMATIC COMPOUNDS

氧化是最基本的有机反应之一。由于地球表面覆盖着含氧空气，保持氧化环境，许多天然产物都是通过氧化反应产生的，这是关键的生物合成反应。本项目发现，4-甲氧基萘酚和4-甲氧基萘胺等芳香族化合物在分子氧的氧化作用下，会发生氧化二聚化，然后环化，分别得到多环化合物、二苯并呋喃醌和二苯并咔唑。

Oxidation is one of the most fundamental organic reactions. Since the surface of the earth is covered with air including oxygen and keeps oxidative environment, many natural products occur via oxidation as the key biosynthetic reaction. In this project, it is found that oxidation of aromatic compounds such as 4-methoxynaphthols and 4-methoxynaphthylamines using molecular oxygen causes oxidative dimerization followed by cyclization to afford polycyclic compounds, dibenzofuranquinones and dibenzocarbazoles, respectively.