CONSTRUCTION OF POLYCYCLIC SYSTEMS USING OXIDATION OF AROMATIC COMPOUNDS

氧化是最基本的有机反应之一。由于地球表面覆盖着含氧的空气并保持着氧化环境，许多天然产物都是通过氧化产生的，而氧化是生物合成的关键反应。在本项目中，我们发现4-甲氧基萘酚和4-甲氧基萘胺等芳香族化合物在分子氧的作用下发生氧化二聚和环合反应，分别得到多环化合物、二苯并呋喃类化合物和二苯并咔唑类化合物。

Oxidation is one of the most fundamental organic reactions. Since the surface of the earth is covered with air including oxygen and keeps oxidative environment, many natural products occur via oxidation as the key biosynthetic reaction. In this project, it is found that oxidation of aromatic compounds such as 4-methoxynaphthols and 4-methoxynaphthylamines using molecular oxygen causes oxidative dimerization followed by cyclization to afford polycyclic compounds, dibenzofuranquinones and dibenzocarbazoles, respectively.