Studies on mechanism of the expression of aquaglyceroporins by insulin and contribution of aquaglyceroporins to glycerol metabolism

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Expression and functional mechanisms of aquaporin (AQP) 3 was investigated using human colon carcinoma cell line (Caco-2). Forkhead box a2 (Foxa2) was suggested to be one of the transcriptional regulators for AQP3 gene expression mediated by insulin. Signal transducers, adenylyl cyclase, protein kinase A, mitogen-activated protein kinase kinase 1/2, and mitogen- and stress-activated protein kinase 1, were demonstrated to be involved in the signaling pathway for regulating transcription of the aquaporin 3 gene and cAMP response element-binding protein is one of the transcriptional regulators for aquaporin 3 gene expression mediated by magnesium ion. Protein kinase C was shown to modulate the externalization of AQP3 by epinephrine.