Expansion of inhibitory NK cell receptor-expressing CD8 T cells and immunoregulatory CD4 T cells
Expansion of inhibitory NK cell receptor-expressing CD8 T cells and immunoregulatory CD4 T cells
批准号:
19591093
负责人:
TANAKA Junji
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
同種造血細胞移植においては移植片対宿主病を抑制しつつ、移植片対白血病効果を誘導することがその安全性と有効性において極めて臨床的に重要である。このような理想的な細胞療法を目指して、臍帯血のCD4陽性分画からCD3/CD28ビーズとIL-15, TGF-bを用いて免疫制御性CD25/CD4細胞 (Treg)を、そしてCD4陰性分画からはOKT3とIL-15を用いて抑制性NK細胞受容体(CD94)発現細胞障害性CD8細胞を同時に増幅しうることを明らかにした。
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A retrospective analysis of allogeneic hematopoietic stem cell transplantation for adult T cell leukemia/lymphoma (ATL) : clinical impact of graft-yersus-leukemia/lymphoma effect
异基因造血干细胞移植治疗成人T细胞白血病/淋巴瘤(ATL)的回顾性分析:移植物-耶尔森-白血病/淋巴瘤效应的临床影响
DOI:
--
发表时间:
2008
期刊:
Biol Blood Marrow Transplant 14
影响因子:
--
作者:
[Shiratori S, Tanaka J, et.al.]
通讯作者:
et.al.
Subpopulations of human NK cells after allogeneic stem cell transplantation
同种异体干细胞移植后人类 NK 细胞亚群
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Tanaka J, Sugita J, Shigematu A, Shiratori S, Wakasa K, Kondo T, Asaka M, Imamura M]
通讯作者:
Imamura M
Ciprofloxacin inhibits lipopolysaccharide-induced toll-like receptor-4 and 8 expression on human monocytes derived from adult and cord blood
环丙沙星抑制脂多糖诱导的成人和脐带血单核细胞中 Toll 样受体 4 和 8 的表达
DOI:
--
发表时间:
2008
期刊:
Ann Hematol 87
影响因子:
--
作者:
[Kaji M, Tanaka J, Sugita J, Kato N, Ibata M, Shono Y, Ota S, Kondo T, Asaka M, Imamura M]
通讯作者:
Imamura M
Expansion of NK receptor (CD94/NKG2A)-expressing cytolytic CD8 T cells and CD4^+CD25^+ regulatory T cells from the same cord blood unit
来自同一脐带血单位的表达 NK 受体 (CD94/NKG2A) 的溶细胞性 CD8 T 细胞和 CD4^ CD25^ 调节性 T 细胞的扩增
DOI:
--
发表时间:
2007
期刊:
Exp Hematol 35
影响因子:
--
作者:
[Tanaka J, Sugita J, Kato N, Toubai T, Ibata M, Shono Y, Ota S, Kondo T, Kobayashi T, Kobayashi M, Asaka M, Imamura M]
通讯作者:
Imamura M
DOI:
10.1016/j.bbmt.2008.02.018
发表时间:
2008-05-01
期刊:
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
影响因子:
4.3
作者:
[Shigematsu, Akio, Kondo, Takeshi, Imamura, Masahiro]
通讯作者:
Imamura, Masahiro
共 25 条
Expansion of activated NK cells from cord bloood
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批准号:22591056
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2010
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负责人:TANAKA Junji
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依托单位:
Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats
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批准号:21590798
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2009
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负责人:TANAKA Junji
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依托单位:
Visceral pain and activation of MAPK in sensory neurons after noxious gastric distension
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批准号:19590740
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
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负责人:TANAKA Junji
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依托单位:
Research for cell therapy using NK cell receptor-expressing T cells against leukemia.
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批准号:17590975
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2005
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负责人:TANAKA Junji
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依托单位:
Allogeneic cell therapy for the regulation of GVHD/GVL
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批准号:15590990
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:TANAKA Junji
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依托单位:
The role of monocytes in the regulation of GVHD after allogeneic stem cell transplantation.
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批准号:11670976
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:1999
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负责人:TANAKA Junji
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依托单位:
Possible effect of splenectomy on liver regeneration in cirrhotic rats.
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批准号:63570629
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1988
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负责人:TANAKA Junji
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依托单位:
Experimental studies of latency and persistence in vitro by human cytomegalovirus
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批准号:61570226
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.22万
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财政年份:1986
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负责人:TANAKA Junji
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依托单位: