Research for cell therapy using NK cell receptor-expressing T cells against leukemia.
Research for cell therapy using NK cell receptor-expressing T cells against leukemia.
批准号:
17590975
负责人:
TANAKA Junji
金额:
$2.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2006
中文摘要
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英文摘要
In this study, we could expand inhibitory NK cell receptor (CD94/NKG2A)-expressing CD8 T cells from G-CSF-mobilized peripheral blood mononuclear cells (G-PBMC), patients' derived autologous G-CSF-mobilized peripheral blood mononuclear cells (Auto G-PBMC) and cord blood by the stimulation of IL-15 and OKT3.These expanded CD94 /NKG2A-expres sing CD8 T cells could attack HLA class I-low leukemic cell line such as K562 and patients' derived primary leukemic cells.Also, it was reveled that activating NK cell receptor NKG2D and it's legand MICA/B were involved in the killing activity of CD94/NKG2A-expressing CD8 T cells.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
The immunosuppressive agent FK506 enhances the cytolytic activity of inhibitory NK cell receptor (CD94/NKG2A)-expressing CD8 T cells.
免疫抑制剂 FK506 增强表达抑制性 NK 细胞受体 (CD94/NKG2A) 的 CD8 T 细胞的细胞溶解活性。
DOI:
--
发表时间:
2005
期刊:
Transplantation 27
影响因子:
--
作者:
[Moriyama K, Tagami T, Usui T, Naruse M, Hataya Y, Kanamoto N, Li Y, Arai H, Akamizu T, Nakao K, Tanaka J et al.]
通讯作者:
Tanaka J et al.
DOI:
10.1038/sj.bmt.1705352
发表时间:
2006-05-01
期刊:
BONE MARROW TRANSPLANTATION
影响因子:
4.8
作者:
[Miura, Y, Tanaka, J, Imamura, M]
通讯作者:
Imamura, M
Expansion of activated NK cells from cord bloood
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批准号:22591056
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2010
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负责人:TANAKA Junji
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依托单位:
Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats
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批准号:21590798
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2009
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负责人:TANAKA Junji
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依托单位:
Expansion of inhibitory NK cell receptor-expressing CD8 T cells and immunoregulatory CD4 T cells
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批准号:19591093
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
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负责人:TANAKA Junji
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依托单位:
Visceral pain and activation of MAPK in sensory neurons after noxious gastric distension
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批准号:19590740
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
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负责人:TANAKA Junji
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依托单位:
Allogeneic cell therapy for the regulation of GVHD/GVL
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批准号:15590990
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:TANAKA Junji
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依托单位:
The role of monocytes in the regulation of GVHD after allogeneic stem cell transplantation.
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批准号:11670976
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:1999
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负责人:TANAKA Junji
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依托单位:
Possible effect of splenectomy on liver regeneration in cirrhotic rats.
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批准号:63570629
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1988
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负责人:TANAKA Junji
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依托单位:
Experimental studies of latency and persistence in vitro by human cytomegalovirus
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批准号:61570226
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.22万
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财政年份:1986
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负责人:TANAKA Junji
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依托单位:
海外基金