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Research for cell therapy using NK cell receptor-expressing T cells against leukemia.

Research for cell therapy using NK cell receptor-expressing T cells against leukemia.
使用表达 NK 细胞受体的 T 细胞对抗白血病的细胞疗法研究。
批准号:
17590975
负责人:
TANAKA Junji
金额:
$2.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2006

项目摘要

项目成果

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中文摘要
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英文摘要
In this study, we could expand inhibitory NK cell receptor (CD94/NKG2A)-expressing CD8 T cells from G-CSF-mobilized peripheral blood mononuclear cells (G-PBMC), patients' derived autologous G-CSF-mobilized peripheral blood mononuclear cells (Auto G-PBMC) and cord blood by the stimulation of IL-15 and OKT3.These expanded CD94 /NKG2A-expres sing CD8 T cells could attack HLA class I-low leukemic cell line such as K562 and patients' derived primary leukemic cells.Also, it was reveled that activating NK cell receptor NKG2D and it's legand MICA/B were involved in the killing activity of CD94/NKG2A-expressing CD8 T cells.
期刊论文(4)
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科研奖励(0)
会议论文
The immunosuppressive agent FK506 enhances the cytolytic activity of inhibitory NK cell receptor (CD94/NKG2A)-expressing CD8 T cells.
免疫抑制剂 FK506 增强表达抑制性 NK 细胞受体 (CD94/NKG2A) 的 CD8 T 细胞的细胞溶解活性。
DOI: --
发表时间: 2005
期刊: Transplantation 27
影响因子: --
作者: [Moriyama K, Tagami T, Usui T, Naruse M, Hataya Y, Kanamoto N, Li Y, Arai H, Akamizu T, Nakao K, Tanaka J et al.]
通讯作者: Tanaka J et al.
DOI: 10.1038/sj.bmt.1705352
发表时间: 2006-05-01
期刊: BONE MARROW TRANSPLANTATION
影响因子: 4.8
作者: [Miura, Y, Tanaka, J, Imamura, M]
通讯作者: Imamura, M
Expansion of activated NK cells from cord bloood
  • 批准号:
    22591056
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.91万
  • 财政年份:
    2010
  • 负责人:
    TANAKA Junji
  • 依托单位:
Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats
  • 批准号:
    21590798
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.91万
  • 财政年份:
    2009
  • 负责人:
    TANAKA Junji
  • 依托单位:
Expansion of inhibitory NK cell receptor-expressing CD8 T cells and immunoregulatory CD4 T cells
  • 批准号:
    19591093
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.91万
  • 财政年份:
    2007
  • 负责人:
    TANAKA Junji
  • 依托单位:
Visceral pain and activation of MAPK in sensory neurons after noxious gastric distension
  • 批准号:
    19590740
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.91万
  • 财政年份:
    2007
  • 负责人:
    TANAKA Junji
  • 依托单位:
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