Regulatory effects of statin reagents on both host responses and viral productions in the infections
Regulatory effects of statin reagents on both host responses and viral productions in the infections
批准号:
19591187
负责人:
TAKAHASHI Takashi
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
動物モデルや細胞実験を用いて、ウイルス感染症におけるスタチン系薬の宿主応答作用と抗ウイルス作用を解析した。肥満マウスのウイルス性心筋炎モデルではウイルス感染前からのスタチンの予防投与によって死亡率の低下が認められ、その機序として腹腔内マクロファージにおける機能や形質の調節が介在することが考えられた。さらに、ヒト胎児肺線維芽細胞へのサイトメガロウイルス感染実験において、スタチンによるウイルス産生の抑制が見られ、宿主細胞における分化増殖に関わる遺伝子群の発現変動が関与している可能性が示唆された。
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スタチンの免疫調節作用
他汀类药物的免疫调节作用
DOI:
--
发表时间:
2009
期刊:
Medical Practice 26
影响因子:
--
作者:
[高橋孝, 石垣靖人, 高野文英]
通讯作者:
高野文英
Association of seroprevalence of human metapneumovirus with C-reactive protein level and apolipoprotein E-ε4 allele in elderly inpatients in Japan
日本老年住院患者人偏肺病毒血清阳性率与 C 反应蛋白水平和载脂蛋白 E-ε4 等位基因的关系
DOI:
--
发表时间:
2008
期刊:
J Am Geriatr Soc 56
影响因子:
--
作者:
[Takashi Takahashi, Koji Nomura, Haruhito Honda, Takeshi Nakahashi, Kunimitsu Iwai, Mikiko Atsumi, Keiichiro Ishigami, Takashi Inamatsu, Shigeto Morimoto]
通讯作者:
Shigeto Morimoto
スタチン系薬剤のヒトサイトメガロウイルスに対する増殖抑制効果
他汀类药物对人巨细胞病毒的生长抑制作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ozaki S., Yamada H., Nagafuchi H., Ooka S., Maeda A., Itoh H, 畢長暁]
通讯作者:
畢長暁
スタチンと感染症
他汀类药物和感染
DOI:
--
发表时间:
2009
期刊:
Medical Practice 26
影响因子:
--
作者:
[高橋孝, 村山次哉]
通讯作者:
村山次哉
Outbreak of norovirus gastroenteritis among elderly evacuees following the 2007 Noto peninsula earthquake in Japan
2007 年日本能登半岛地震后,老年疏散人员中爆发诺如病毒胃肠炎
DOI:
--
发表时间:
2008
期刊:
J Am Geriatr Soc 56
影响因子:
--
作者:
[Koji Nomura, Hiroshi Murai, Takeshi Nakahashi, Satoru Mashiba, Yukihiro Watoh, Takashi Takahashi, Sigeto Morimoto]
通讯作者:
Sigeto Morimoto
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Image pattern recognition in eigenspace of local features
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Integrated system of the tailor-made cancer treatment based on the expression profiling and bioinformatic analyses
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Solid-and Solution-Phase Synthesis of Natural Product-Based Libraries
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Study on Drug-Resistance of Pneumocystis carinii
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Multifaceted analysis of molecular pathogenesis of human lung cancers
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Molecular Biological Study on Hospital-Acquired Infections and Drug-Resistance of Pneumocystis carinii
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A Quasi-Experimental Study on Design Education
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High-resolution angle-resolved photoemission study of electronic structure near the Fermi level in strongly correlated f-electron materials
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Genetic changes in the pathogenesis of lung cancer
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Development of New Synthetic Methods for Steroid Sleketon Based on Theoretical Calculation
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Development of high-energy resolution photoemission spectrometer and study of the electronic structure near the Fermi level
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Design and Synthesis of Taxol Skeleton on the Basis of Molecular Mechanics Calculations
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A Study of Environmental Behavior in town area
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海外基金