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Study on Drug-Resistance of Pneumocystis carinii

Study on Drug-Resistance of Pneumocystis carinii
卡氏肺孢子虫耐药性研究
批准号:
14570232
负责人:
TAKAHASHI Takashi
金额:
$2.24万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2002
资助国家:
日本
项目状态:
已结题
起止时间:
2002 至 2003

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中文摘要
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英文摘要
We examined ammo acid mutations in dihydrofolate reductase (DHFR) of Pneumocystis carinii (Pc) isolated from 34 patients with Pc pneumonia in Japan. DHFR mutations (Ala67Val, Cys166Tyr) were observed in the two different patients. However, they were successfully treated with trimethoprim-sulfamethoxazole.Pc or Cryptococcus neoformans (Cn) carriage was determined in 78 immunocompromised subjects with or without human immunodeficiency virus. Pc colonization in the respiratory tract was round for this population, while no patients colonized with Cn were experienced.We started cohort study including HIV patients in Thailand (Lampang Provincial Hospital) in August 2003. Amino acid substitutions of the drug-target enzymes in the Pc will be analyzed with the samples of sputum induction.
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Takahashi T, Endo T, et al.: "Dihydrofolate reductase gene polymorphisms in Pneumocystis carinii f.sp.hominis in Japan."J Med Microbiol. 51,6. 510-515 (2002)
Takahashi T、Endo T 等人:“日本卡氏肺囊虫人型肺孢子虫中的二氢叶酸还原酶基因多态性。”J Med Microbiol。
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通讯作者:
Takahashi, T., Endo, T., et al.: "Dihydrofolate reductase gene polymorphisms in Pneumocystis carinii f. sp. hominis in Japan"J Med Microbiol. 51.6. 510-515 (2002)
Takahashi, T., Endo, T., et al.:“日本卡氏肺囊虫人型肺孢子菌二氢叶酸还原酶基因多态性”J Med Microbiol。
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H Yamada, H Kotaki, T Takahashi: "Recommendations for the treatment of fungal pneumonias."Expert Opin Pharmacother. 4,8. 1241-1258 (2003)
H Yamada、H Kotaki、T Takahashi:“治疗真菌性肺炎的建议。”专家药理学家意见。
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通讯作者:
Takahashi T, Endo T, et al.: "Dihydrofolate reductase gene polymorphisms in Pneumocystis carinii f. s hominis in Japan"Journal of Medical Microbiology. 51-6. 510-515 (2002)
Takahashi T、Endo T 等人:“日本卡氏肺孢子虫 f. s hominis 中的二氢叶酸还原酶基因多态性”医学微生物学杂志。
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12
    Identification of host factors contributing to host intercellular translocation of Group A Streptococci which causes invasive infections
    • 批准号:
      25670469
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2013
    • 负责人:
      TAKAHASHI Takashi
    • 依托单位:
    Electronic states of novel functional materials studied by ultrahigh-resolution three-dimensional spin- and angle-resolved photoemission spectroscopy
    • 批准号:
      23224010
    • 项目类别:
      Grant-in-Aid for Scientific Research (S)
    • 资助金额:
      $135.03万
    • 财政年份:
      2011
    • 负责人:
      TAKAHASHI Takashi
    • 依托单位:
    MRM・MS and microRNA profiling analyses of blood samples and their clinical applications for development of molecular diagnostics
    • 批准号:
      21249037
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $27.04万
    • 财政年份:
      2009
    • 负责人:
      TAKAHASHI Takashi
    • 依托单位:
    Determining molecular mechanisms of statin regulatoryeffects on host and viral responses in the infections
    • 批准号:
      21390306
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.9万
    • 财政年份:
      2009
    • 负责人:
      TAKAHASHI Takashi
    • 依托单位:
    海外基金