Study on Drug-Resistance of Pneumocystis carinii
卡氏肺孢子虫耐药性研究
基本信息
- 批准号:14570232
- 负责人:
- 金额:$ 2.24万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2002
- 资助国家:日本
- 起止时间:2002 至 2003
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We examined ammo acid mutations in dihydrofolate reductase (DHFR) of Pneumocystis carinii (Pc) isolated from 34 patients with Pc pneumonia in Japan. DHFR mutations (Ala67Val, Cys166Tyr) were observed in the two different patients. However, they were successfully treated with trimethoprim-sulfamethoxazole.Pc or Cryptococcus neoformans (Cn) carriage was determined in 78 immunocompromised subjects with or without human immunodeficiency virus. Pc colonization in the respiratory tract was round for this population, while no patients colonized with Cn were experienced.We started cohort study including HIV patients in Thailand (Lampang Provincial Hospital) in August 2003. Amino acid substitutions of the drug-target enzymes in the Pc will be analyzed with the samples of sputum induction.
我们研究了从日本34例卡氏肺孢子虫肺炎患者中分离的卡氏肺孢子虫(Pc)二氢叶酸还原酶(DHFR)的氨基酸突变。在两个不同的患者中观察到DHFR突变(Ala 67 Val,Cys 166 Tyr)。然而,他们成功地治疗与甲氧苄啶-磺胺甲恶唑。Pc或隐球菌(Cn)的载体进行了测定,在78个免疫功能低下的受试者有或没有人类免疫缺陷病毒。Pc在呼吸道的殖民是圆的这个人口,而没有患者与Cn殖民experienced.We开始队列研究,包括艾滋病毒患者在泰国(南邦省医院)在2003年8月。将使用痰液诱导样本分析Pc中药物靶向酶的氨基酸取代。
项目成果
期刊论文数量(24)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Takahashi T, Endo T, et al.: "Dihydrofolate reductase gene polymorphisms in Pneumocystis carinii f.sp.hominis in Japan."J Med Microbiol. 51,6. 510-515 (2002)
Takahashi T、Endo T 等人:“日本卡氏肺囊虫人型肺孢子虫中的二氢叶酸还原酶基因多态性。”J Med Microbiol。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Takahashi, T., Endo, T., et al.: "Dihydrofolate reductase gene polymorphisms in Pneumocystis carinii f. sp. hominis in Japan"J Med Microbiol. 51.6. 510-515 (2002)
Takahashi, T., Endo, T., et al.:“日本卡氏肺囊虫人型肺孢子菌二氢叶酸还原酶基因多态性”J Med Microbiol。
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- 影响因子:0
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H Yamada, H Kotaki, T Takahashi: "Recommendations for the treatment of fungal pneumonias."Expert Opin Pharmacother. 4,8. 1241-1258 (2003)
H Yamada、H Kotaki、T Takahashi:“治疗真菌性肺炎的建议。”专家药理学家意见。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Takahashi T, Endo T, et al.: "Dihydrofolate reductase gene polymorphisms in Pneumocystis carinii f. s hominis in Japan"Journal of Medical Microbiology. 51-6. 510-515 (2002)
Takahashi T、Endo T 等人:“日本卡氏肺孢子虫 f. s hominis 中的二氢叶酸还原酶基因多态性”医学微生物学杂志。
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- 影响因子:0
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- 通讯作者:
Takahashi T, Goto M, et al.: "Pneumocystis carinii carriage in immunocompromised patients with and without human immunodeficiency virus infection"Journal of Medical Microbiology. 51-7. 611-614 (2002)
Takahashi T、Goto M 等人:“患有和不患有人类免疫缺陷病毒感染的免疫功能低下患者中携带卡氏肺孢子虫”医学微生物学杂志。
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- 影响因子:0
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TAKAHASHI Takashi其他文献
TAKAHASHI Takashi的其他文献
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{{ truncateString('TAKAHASHI Takashi', 18)}}的其他基金
Identification of host factors contributing to host intercellular translocation of Group A Streptococci which causes invasive infections
鉴定导致 A 族链球菌宿主细胞间易位(导致侵袭性感染)的宿主因素
- 批准号:
25670469 - 财政年份:2013
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Electronic states of novel functional materials studied by ultrahigh-resolution three-dimensional spin- and angle-resolved photoemission spectroscopy
通过超高分辨率三维自旋和角分辨光电子能谱研究新型功能材料的电子态
- 批准号:
23224010 - 财政年份:2011
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (S)
MRM・MS and microRNA profiling analyses of blood samples and their clinical applications for development of molecular diagnostics
血液样本的 MRM・MS 和 microRNA 分析及其在分子诊断开发中的临床应用
- 批准号:
21249037 - 财政年份:2009
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Determining molecular mechanisms of statin regulatoryeffects on host and viral responses in the infections
确定他汀类药物对感染中宿主和病毒反应的调节作用的分子机制
- 批准号:
21390306 - 财政年份:2009
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Regulatory effects of statin reagents on both host responses and viral productions in the infections
他汀类药物试剂对感染中宿主反应和病毒产生的调节作用
- 批准号:
19591187 - 财政年份:2007
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Image pattern recognition in eigenspace of local features
局部特征特征空间中的图像模式识别
- 批准号:
18700234 - 财政年份:2006
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Molecular dissection of molecular pathogenesis of lung cancer towards realization of personalized medicine
解析肺癌分子发病机制,实现个体化医疗
- 批准号:
17015019 - 财政年份:2005
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Integrated system of the tailor-made cancer treatment based on the expression profiling and bioinformatic analyses
基于表达谱和生物信息分析的定制癌症治疗集成系统
- 批准号:
15390181 - 财政年份:2003
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of ultrahigh-resolution photoemission spectrometer and study of quasiparticles in high-temperature superconductors
超高分辨率光电子能谱仪研制及高温超导准粒子研究
- 批准号:
14102006 - 财政年份:2002
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (S)
Solid-and Solution-Phase Synthesis of Natural Product-Based Libraries
基于天然产物的文库的固相和溶液相合成
- 批准号:
14103013 - 财政年份:2002
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (S)
相似海外基金
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- 批准号:
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