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Molecular dissection of molecular pathogenesis of lung cancer towards realization of personalized medicine

Molecular dissection of molecular pathogenesis of lung cancer towards realization of personalized medicine
解析肺癌分子发病机制,实现个体化医疗
批准号:
17015019
负责人:
TAKAHASHI Takashi
金额:
$102.27万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009

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中文摘要
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英文摘要
Our multi-faceted approach towards a better understanding of lung cancer pathogenesis revealed that two major expression profile-defined subtypes exist in lung adenocarcinomas and that TTF-1 confers lineage-specific dependency in lung adenocarcinomas. In addition, we identified mRNA and protein expression signatures highly related to postoperative prognosis, while we also found relationship between deregulation of mTOR-converging signaling and poor prognosis. Finally, we reported for the first time that let-7 is reduced, while miR-17-92 is overexpressed in lung cancers, suggesting important roles of miRNA alterations in lung carcinogenesis.
期刊论文(119)
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会议论文
DOI: 10.1186/1471-2164-8-98
发表时间: 2007-04-11
期刊: BMC genomics
影响因子: 4.4
作者: [Ranganathan P, Agrawal A, Bhushan R, Chavalmane AK, Kalathur RK, Takahashi T, Kondaiah P]
通讯作者: Kondaiah P
DOI: 10.1158/0008-5472.can-07-1749
发表时间: 2007-12-01
期刊: CANCER RESEARCH
影响因子: 11.2
作者: [Ebi, Hiromichi, Matsuo, Keitaro, Takahashi, Takashi]
通讯作者: Takahashi, Takashi
Improved integrative "omics" view and an unresolved question in lung cancer pathoeenesis (ラークショップ)
肺癌发病机制中综合“组学”观点的改进和未解之谜(飞书店)
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Otsubo T, Akiyama Y, Yanagihara K, Yuasa Y, Takahashi T]
通讯作者: Takahashi T
細胞増殖阻害剤
细胞生长抑制剂
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: []
通讯作者:
83
    Identification of host factors contributing to host intercellular translocation of Group A Streptococci which causes invasive infections
    • 批准号:
      25670469
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2013
    • 负责人:
      TAKAHASHI Takashi
    • 依托单位:
    Electronic states of novel functional materials studied by ultrahigh-resolution three-dimensional spin- and angle-resolved photoemission spectroscopy
    • 批准号:
      23224010
    • 项目类别:
      Grant-in-Aid for Scientific Research (S)
    • 资助金额:
      $135.03万
    • 财政年份:
      2011
    • 负责人:
      TAKAHASHI Takashi
    • 依托单位:
    MRM・MS and microRNA profiling analyses of blood samples and their clinical applications for development of molecular diagnostics
    • 批准号:
      21249037
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $27.04万
    • 财政年份:
      2009
    • 负责人:
      TAKAHASHI Takashi
    • 依托单位:
    Determining molecular mechanisms of statin regulatoryeffects on host and viral responses in the infections
    • 批准号:
      21390306
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.9万
    • 财政年份:
      2009
    • 负责人:
      TAKAHASHI Takashi
    • 依托单位:
    海外基金