Molecular dissection of molecular pathogenesis of lung cancer towards realization of personalized medicine
Molecular dissection of molecular pathogenesis of lung cancer towards realization of personalized medicine
批准号:
17015019
负责人:
TAKAHASHI Takashi
金额:
$102.27万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
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英文摘要
Our multi-faceted approach towards a better understanding of lung cancer pathogenesis revealed that two major expression profile-defined subtypes exist in lung adenocarcinomas and that TTF-1 confers lineage-specific dependency in lung adenocarcinomas. In addition, we identified mRNA and protein expression signatures highly related to postoperative prognosis, while we also found relationship between deregulation of mTOR-converging signaling and poor prognosis. Finally, we reported for the first time that let-7 is reduced, while miR-17-92 is overexpressed in lung cancers, suggesting important roles of miRNA alterations in lung carcinogenesis.
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DOI:
10.1186/1471-2164-8-98
发表时间:
2007-04-11
期刊:
BMC genomics
影响因子:
4.4
作者:
[Ranganathan P, Agrawal A, Bhushan R, Chavalmane AK, Kalathur RK, Takahashi T, Kondaiah P]
通讯作者:
Kondaiah P
DOI:
10.1158/0008-5472.can-07-1749
发表时间:
2007-12-01
期刊:
CANCER RESEARCH
影响因子:
11.2
作者:
[Ebi, Hiromichi, Matsuo, Keitaro, Takahashi, Takashi]
通讯作者:
Takahashi, Takashi
Improved integrative "omics" view and an unresolved question in lung cancer pathoeenesis (ラークショップ)
肺癌发病机制中综合“组学”观点的改进和未解之谜(飞书店)
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Otsubo T, Akiyama Y, Yanagihara K, Yuasa Y, Takahashi T]
通讯作者:
Takahashi T
細胞増殖阻害剤
细胞生长抑制剂
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[]
通讯作者:
The ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features.
ASH1基因是具有神经内分泌特征的肺癌的特异性治疗靶点。
DOI:
--
发表时间:
2005
期刊:
Cancer Research 65
影响因子:
--
作者:
[Osada, H., et al.]
通讯作者:
et al.
共 83 条
Identification of host factors contributing to host intercellular translocation of Group A Streptococci which causes invasive infections
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批准号:25670469
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2013
-
负责人:TAKAHASHI Takashi
-
依托单位:
Electronic states of novel functional materials studied by ultrahigh-resolution three-dimensional spin- and angle-resolved photoemission spectroscopy
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批准号:23224010
-
项目类别:Grant-in-Aid for Scientific Research (S)
-
资助金额:$135.03万
-
财政年份:2011
-
负责人:TAKAHASHI Takashi
-
依托单位:
MRM・MS and microRNA profiling analyses of blood samples and their clinical applications for development of molecular diagnostics
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批准号:21249037
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$27.04万
-
财政年份:2009
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负责人:TAKAHASHI Takashi
-
依托单位:
Determining molecular mechanisms of statin regulatoryeffects on host and viral responses in the infections
-
批准号:21390306
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.9万
-
财政年份:2009
-
负责人:TAKAHASHI Takashi
-
依托单位:
Regulatory effects of statin reagents on both host responses and viral productions in the infections
-
批准号:19591187
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2007
-
负责人:TAKAHASHI Takashi
-
依托单位:
Image pattern recognition in eigenspace of local features
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批准号:18700234
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.02万
-
财政年份:2006
-
负责人:TAKAHASHI Takashi
-
依托单位:
Integrated system of the tailor-made cancer treatment based on the expression profiling and bioinformatic analyses
-
批准号:15390181
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.06万
-
财政年份:2003
-
负责人:TAKAHASHI Takashi
-
依托单位:
Development of ultrahigh-resolution photoemission spectrometer and study of quasiparticles in high-temperature superconductors
-
批准号:14102006
-
项目类别:Grant-in-Aid for Scientific Research (S)
-
资助金额:$69.97万
-
财政年份:2002
-
负责人:TAKAHASHI Takashi
-
依托单位:
Solid-and Solution-Phase Synthesis of Natural Product-Based Libraries
-
批准号:14103013
-
项目类别:Grant-in-Aid for Scientific Research (S)
-
资助金额:$64.4万
-
财政年份:2002
-
负责人:TAKAHASHI Takashi
-
依托单位:
Study on Drug-Resistance of Pneumocystis carinii
-
批准号:14570232
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2002
-
负责人:TAKAHASHI Takashi
-
依托单位:
Multifaceted analysis of molecular pathogenesis of human lung cancers
-
批准号:12213163
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$58.18万
-
财政年份:2000
-
负责人:TAKAHASHI Takashi
-
依托单位:
Molecular Biological Study on Hospital-Acquired Infections and Drug-Resistance of Pneumocystis carinii
-
批准号:11670439
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:1999
-
负责人:TAKAHASHI Takashi
-
依托单位:
Development of solid-phase methodology for the synthesis of combinatorial library
-
批准号:11305065
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$26.34万
-
财政年份:1999
-
负责人:TAKAHASHI Takashi
-
依托单位:
A Quasi-Experimental Study on Design Education
-
批准号:11450221
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$5.06万
-
财政年份:1999
-
负责人:TAKAHASHI Takashi
-
依托单位:
High-resolution angle-resolved photoemission study of electronic structure near the Fermi level in strongly correlated f-electron materials
-
批准号:10440097
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.19万
-
财政年份:1998
-
负责人:TAKAHASHI Takashi
-
依托单位:
Genetic changes in the pathogenesis of lung cancer
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批准号:09253256
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$19.2万
-
财政年份:1997
-
负责人:TAKAHASHI Takashi
-
依托单位:
Development of New Synthetic Methods for Steroid Sleketon Based on Theoretical Calculation
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批准号:08555227
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$2.69万
-
财政年份:1996
-
负责人:TAKAHASHI Takashi
-
依托单位:
Development of high-energy resolution photoemission spectrometer and study of the electronic structure near the Fermi level
-
批准号:07404017
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$16.96万
-
财政年份:1995
-
负责人:TAKAHASHI Takashi
-
依托单位:
Design and Synthesis of Taxol Skeleton on the Basis of Molecular Mechanics Calculations
-
批准号:07458141
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.93万
-
财政年份:1995
-
负责人:TAKAHASHI Takashi
-
依托单位:
A Study of Environmental Behavior in town area
-
批准号:06402047
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$10.43万
-
财政年份:1994
-
负责人:TAKAHASHI Takashi
-
依托单位:
海外基金