Establishment of Immunosuppressive Therapy by Regulatory T cells Induced Type V Collagen with Immunosuppressive Medication

口服V型胶原[col(V)] +低剂量环孢素（CsA）可消除MHC完全不相容大鼠肺移植的排斥反应。Col(V)加CsA下调同种异体抗原诱导的ifn - γ和IL-17A的产生，并与受体T细胞中同种异体抗原诱导的IL-10表达相关。这些数据表明col(V)增强低剂量csa介导的免疫抑制，并提示口服col(V)在肺移植免疫调节中的作用。

Oral administration of type V collagen [col(V)] plus low-dose cyclosporine (CsA) was abrogates rejection of fully MHC incompatible rat lung allograft. Col(V) plus CsA was down-regulated alloantigen-induced production of IFN-gamma and IL-17A and associated with alloantigen-induced expression of IL-10 in recipient T cells. These data demonstrate that col(V) enhances low-dose CsA-mediated immune suppression, and suggest a role for oral col(V) in immune modulation in lung transplantation.