Possibility of cadaver lung transplantation by the regenerative medicine using type II alveolar epithelial cells

我们建立了II型肺泡上皮细胞（AT-II）的分离。我们证实了大鼠左肺切除后移植的AT-II细胞在右肺的移植。分析了人AT-II细胞的功能，并证实了转移的人AT-II细胞在免疫缺陷大鼠体内的移植。建立大鼠肺缺血再灌注损伤模型。探讨at - ii细胞在肺损伤模型中再生肺损伤的可能性，以尸体供肺为指征。

We established isolation of the type II alveolar epithelial cells (AT-II). We confirmed the engraftment of the transplanted AT-II cells to the right lung after left pneumonectomized rats. Human AT-II cells functions were analyzed and the engraftment of transferred human AT-II cells to immunodeficient rats were confirmed. And we established the ischemia-reperfusion injury lung model in rat. To investigate the potential to regenerate lung injury by transferred AT-II cells in the lung injury model, aimed at indications of cadaveric donor lung.