Establishment of diagnostic method of causative drug by detection of CD40 ligand expression in acute stage of drug eruption

药疹急性期CD40配体表达检测药物诊断方法的建立

• 批准号: 19790776
• 负责人: HIGUCHI Tetsuya
• 金额: $ 2.2万
• 依托单位: Toho University (2008-2009)Tokyo Medical and Dental University (2007)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790776/
• 关键词: 薬疹; CD40リガンド; CD154; フローサイトメトリー; CD40; 皮膚診断学

Upregulation of CD40 ligand, an activated T cell marker, was evaluated to be used as a diagnostic method of causative drug for patients with drug eruption. For patients clinically diagnosed as drug eruption, detection of CD40 ligand on peripheral blood mononuclear was compared with the results of conventional drug tests, such as patch test, lymphocyte transforming test and provocation test. In about two third of patients, whose causative drug was confirmed, CD40 ligand detection test was positive, and this method was suggested to be used clinically.

研究了活化T细胞标志物CD40配体的上调作为药疹患者病原药物的诊断方法。对临床诊断为药疹的患者，将外周血单个核CD40配体检测结果与常规药物试验（如斑贴试验、淋巴细胞转化试验、激发试验）结果进行比较。在确诊致病药物的患者中，约三分之二的患者CD40配体检测试验呈阳性，建议临床应用该方法。

项目成果

An attempt to detect antigen -specific T cells in drug eruption.

尝试检测药疹中的抗原特异性 T 细胞。

• 发表时间: 2010
• 作者: Tetsuya Higuchi;Takahiro Satoh;Hiroo Yokozeki
• 通讯作者: Hiroo Yokozeki

CD40L発現を指標とした薬疹の原因薬剤診断法

以CD40L表达为指标诊断药疹原因

• 发表时间: 2008
• 作者: 樋口哲也;佐藤貴浩;横関博雄
• 通讯作者: 横関博雄