Fabrication of carbonate apatite bone substitute which can be created as an arbitrary shape

可制成任意形状的碳酸盐磷灰石骨替代物的制造

• 批准号: 19791446
• 负责人: SUZUKI Yumiko
• 金额: $ 2.65万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19791446/
• 关键词: インプラント; 骨補填材; ハイドロキシアパタイト; 炭酸アパタイト

The aim of this study was to fabricate the low-crystalline, carbonate apatite block as a bone substitute material. First of all, set gypsum was immersed in several kinds of phosphate aqueous solution.After hydrothermal treatment, set gypsum converted to low-crystalline carbonate apatite retaining its original shape. Analysis of fabricated specimen showed that component is similar to that of natural bone except strength.Investigation of the biocompatibility of the fabricated specimen in vitro was performed. As a result, it was demonstrated that specimen showed no adverse effect on either osteoblast-like cells or osteoclasts.Following the in vitro experiment, animal experiment was performed. As a result, direct bone deposition to the specimen is detected. Howship's lacuna formed by multinucleated cells suppose There are some cells which have a similar morphology of osteoblast around the specimen.We concluded that this is a useful bone filler fabrication method since low-crystalline carbonate apatite same as the shape of bone defect could be fabricated.d to be osteoclasts, are observed around the specimen.

这项研究的目的是制造低结晶的碳酸盐磷灰石块作为骨替代物质。首先，将石膏浸入了几种类型的磷酸盐水溶液中。水热处理后，固定石膏转化为低晶碳酸盐磷酸磷酸磷灰石，以保持其原始形状。对制造的标本的分析表明，除了强度外，成分与天然骨的分量相似。进行了对制造的标本的生物相容性进行了研究。结果，证明了标本对成骨细胞样细胞或骨质细胞没有不利影响。遵循体外实验，进行了动物实验。结果，检测到直接的骨沉积到样品中。多核细胞形成的Howship的空隙认为，有些细胞在标本周围具有类似的成骨细胞形态。我们得出的结论是，这是一种有用的骨填充方法，因为低晶型碳酸盐磷酸磷灰石磷灰石与骨缺损的形状相同。