Fabrication of hydroxyapatite block from gypsum block based on (NH4)2HPO4 treatment.

基于 (NH4)2HPO4 处理从石膏块制备羟基磷灰石块。

• 批准号: 23592889
• 负责人: SUZUKI Yumiko
• 金额: $ 3.16万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592889/
• 关键词: アパタイト; 骨; インプラント; 低結晶性炭酸アパタイト; 骨芽細胞; インプラント治療; 国際研究者交流; 骨増生; 人工骨; ティッシュエンジニアリング; 炭酸アパタイト

The aim of this study was to evaluate the feasibility of fabricating low-crystalline, porous apatite block using set gypsum as a precursor based on the fact that apatite is thermodynamically more stable than gypsum. The transformation reaction caused a release of sulfate ions due to an ion exchange with phosphate ions, thus leading to a decrease in the pH of the solution. Then, due to decreased pH, dicalcium phosphate anhydrous--which has similar thermodynamic stability at lower pH--was also produced as a by-product. Apatite formed in the present method was low-crystalline, porous B-type carbonate apatite that contained approximately 0.5 wt% CO3, even though no carbonate sources--except carbon dioxide from air--were added to the reaction system. We concluded therefore that this is a useful bone filler fabrication method since B-type carbonate apatite is the biological apatite contained in bone.

本研究的目的是基于磷灰石在热力学上比石膏更稳定这一事实，评估以石膏为前驱体制备低结晶、多孔磷灰石块的可行性。由于与磷酸根离子的离子交换，转化反应导致硫酸盐离子的释放，从而导致溶液的pH降低。然后，由于pH降低，副产物无水磷酸氢钙也作为副产物产生--在较低pH下具有类似的热力学稳定性。在本方法中形成的磷灰石是低结晶、多孔的B型碳酸盐磷灰石，其含有大约0.5wt%的CO3，即使没有碳酸盐来源--除了来自空气的二氧化碳--添加到反应体系中。因此，我们得出结论，由于B型碳酸盐磷灰石是骨中含有的生物磷灰石，因此这是一种有用的骨填充材料制备方法。

项目成果

Newly fabricated osteoconductive carbonate apatite bone graft material. An in vivo study

新制备的骨传导碳酸盐磷灰石骨移植材料。

• 发表时间: 2013
• 作者: Masuzaki T;Ayukawa Y;Atsuta I;Jinno Y;Kono T;Koyano K.
• 通讯作者: Koyano K.