Development of organocatalysis aiming for the preparation of important synthetic intermediates

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An efficient one-pot synthesis of various unsymmetrical benzils and heterocycles has been developed. NHC-catalyzed aroylation of N-phenylimidoyl chlorides with aromatic aldehydes followed by acidic hydrolysis gives benzils. A one-pot synthesis of quinoxalines and pyrazines by condensation/cyclization reaction of unsymmetrical benzils generated in situ with diamines was also achieved.Novel C_2-symmetrical imidazolium salts were synthesized and used in kinetic resolution of secondary alcohols and in asymmetric cyanosilylation as a catalyst precursor. It was found out that substituents at 4-and 5-position of imidazole increase the reaction rates.