Development of highly atom-economical synthetic methods based on catalytic cascade reactions

本文综述了基于C-H键活化和多组分反应等原子经济性反应的催化级联合成方法的发展。因此，已经开发了几种用于构建稠合杂环如吲哚、异喹啉、异吲哚、咔唑和喹唑啉的方法。在此基础上，实现了麦角生物碱和茉莉碱B的全合成，以及三氟甲基烯二肽电子等排体的高效合成。这些结果为有效的有机合成提供了初步的模型。

The author investigated development of synthetic methods based on catalytic cascade of atom-economical reactions such as C-H bond activation and multi-component reactions. Consequently, several methods for construction of fused heterocycles such as indoles, isoquinolines, isoindoles, carbazoles, and quinazolines have been developed. Furthermore, total syntheses of ergot alkaloids and jaspine B, as well as efficient synthesis of trifluoromethylalkene dipeptide isosteres have been achieved. These results provide a preliminary model for efficient organic synthesis.