Abdominal obesity measured by multiple sliced CT, plasma adiponectin and colorectal adenoma

多层CT测量腹部肥胖、血浆脂联素和结直肠腺瘤

• 批准号: 19689014
• 负责人: SASAZUKI Shizuka
• 金额: $ 17.72万
• 依托单位: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19689014/
• 关键词: 内臓脂肪; 大腸腺腫; アデイポネクチン; アディポネクチン; アデポネクチン

Among 1,205 eligible subjects who underwent PET-CT for cancer screening in Tokyo, visceral fat volume was associated with the prevalence of colorectal adenoma independently of body mass index in both sexes. Plasma level of C-peptide and IGFBP-1 were associated with colorectal adenoma among men but not women. An inverse and positive association of adiponectin and leptin was observed with colorectal adenoma, respectively.

在东京接受PET-CT癌症筛查的1205名合格受试者中，内脏脂肪体积与结直肠腺瘤的患病率之间存在关联，而不受体重指数的影响。血浆C-肽和IGFBP-1水平与男性结直肠腺瘤相关，但与女性无关。脂联素和瘦素分别与结直肠腺瘤呈负相关和正相关。

项目成果

Development of an automated 3D segmentation program for volume quantification of body fat distribution using CT.

• DOI: 10.6009/jjrt.64.1177
• 发表时间: 2008-09
• 期刊: Nihon Hoshasen Gijutsu Gakkai zasshi
• 作者: S. Ohshima;Shuji Yamamoto;T. Yamaji;Masahiro Suzuki;M. Mutoh;M. Iwasaki;S. Sasazuki;Ken Kotera;S. Tsugane;Y. Muramatsu;N. Moriyama

Dietary isoflavone and the risk of colorectal adenoma: a case-control study in Japan.

膳食异黄酮与结直肠腺瘤的风险：日本的一项病例对照研究。

• DOI: 10.1038/sj.bjc.6605088
• 发表时间: 2009-06-02
• 期刊: BRITISH JOURNAL OF CANCER
• 影响因子: 8.8
• 作者: Akhter, M.;Iwasaki, M.;Yamaji, T.;Sasazuki, S.;Tsugane, S.
• 通讯作者: Tsugane, S.

Methionine synthase A2756G多型と大腸腺腫との関連

蛋氨酸合酶A2756G多态性与结直肠腺瘤的相关性

• 发表时间: 2009
• 作者: 山地大樹;岩崎基;笹月静;坂本裕美;吉田輝彦;津金昌一郎
• 通讯作者: 津金昌一郎

Visceral Fat Volume and the Prevalence of Colorectal Adenoma

• DOI: 10.1093/aje/kwp311
• 发表时间: 2009-12-15
• 期刊: AMERICAN JOURNAL OF EPIDEMIOLOGY
• 影响因子: 5
• 作者: Yamaji, Taiki;Iwasaki, Motoki;Tsugane, Shoichiro
• 通讯作者: Tsugane, Shoichiro

Methionine Synthase A2756G Polymorphism Interacts with Alcohol and Folate Intake to Influence the Risk of Colorectal Adenoma

• DOI: 10.1158/1055-9965.epi-08-0702
• 发表时间: 2009-01-01
• 期刊: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
• 影响因子: 3.8
• 作者: Yamaji, Taiki;Iwasaki, Motoki;Tsugane, Shoichiro
• 通讯作者: Tsugane, Shoichiro