Characterization of novel mechanism of isoniazid resistance

异烟肼耐药新机制的表征

• 批准号: 19790331
• 负责人: SEKIGUCHI Jun-ichiro
• 金额: $ 2.42万
• 依托单位: Research Institute, International Medical Center of Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790331/
• 关键词: 結核; イソニアジド; 薬剤耐性; 多剤耐性結核菌; 耐性機序

Mutations not previously reported in katG and novel isoniazid-resistant genes were detected in Mycobacterium tuberculosis clinical isolates. All mutations were characterized and confirmed that these were associated with isoniazid resistance. This study will contribute further understanding of isoniazid resistance and development of antituberculosis drugs.

在结核分枝杆菌临床分离株中检测到以前未报道的katG和新型异烟肼耐药基因突变。所有突变都被鉴定并证实与异烟肼耐药性有关。本研究将有助于进一步了解异烟肼耐药性和开发抗结核药物。

项目成果

Development and evaluation of a line probe assay for rapid identification of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis strains

• DOI: 10.1128/jcm.00352-07
• 发表时间: 2007-09-01
• 期刊: JOURNAL OF CLINICAL MICROBIOLOGY
• 影响因子: 9.4
• 作者: Sekiguchi, Jun-Ichiro;Nakamura, Tomohiko;Kirikae, Teruo
• 通讯作者: Kirikae, Teruo

Rapid and simple method for detecting qacA, mecA and femB in antiseptics- and methicillin-resistant Staphylococcus aureus by loop-mediated isothermal amplification.

通过环介导等温扩增快速、简单地检测防腐剂和耐甲氧西林金黄色葡萄球菌中的 qacA、mecA 和 femB。

• 发表时间: 2007
• 作者: Sekiguchi J;Mizuguchi Y;Araake M;Watari H;Kojima T;Miyoshi-Akiyama T;Morita K;Kuratsuji T;Kirikae T
• 通讯作者: Kirikae T

KHM-1, a novel plasmid-mediated metallo-beta-lactamase from a Citrobacter freundii clinical isolate.

KHM-1，一种来自弗氏柠檬酸杆菌临床分离株的新型质粒介导的金属-β-内酰胺酶。

• 发表时间: 2008
• 期刊: Antimicrob Agents Chemother 52
• 作者: Sekiguchi J;et al.
• 通讯作者: et al.