Study on the mechanisms of human placental trophoblast syncytialisation : implication for the pathogenesis of pre-eclampsia

人胎盘滋养层合胞化机制的研究：对先兆子痫发病机制的启示

• 批准号: 19591895
• 负责人: KUDO Yoshiki
• 金额: $ 2.91万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591895/
• 关键词: 胎盤; トロフォブラスト; 妊娠高血圧症候群

We have demonstrated that CD98 surface antigen, syncytin, an envelope gene of HERV-W (human endogenous retrovirus-W), and its receptor type D mammalian retrovirus receptor (ASCT2) are involved in the process of cell fusion necessary for syncytiotrophoblast formation using a cell model of syncytialisation (the cytotrophoblast cell line BeWo following increased intracellular cAMP by forskolin treatment).

我们已经证明，CD98表面抗原，合胞素，HERV-W（人类内源性逆转录病毒- w）的包膜基因，及其受体D型哺乳动物逆转录病毒受体（ASCT2）参与细胞融合过程，这是形成合胞滋养层细胞所必需的，使用细胞合胞模型（细胞滋养层细胞系BeWo经过forskolin处理后细胞内cAMP增加）。

项目成果

Circulating endothelial progenitor cells and placental abruption.

循环内皮祖细胞和胎盘早剥。

• 发表时间: 2009
• 作者: Sakashita T;Kudo Y
• 通讯作者: Kudo Y

Hypoxia suppresses expression of syncytin and cell fusion during syncytialisation of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia

缺氧抑制人胎盘 BeWo 细胞合胞化过程中合胞素的表达和细胞融合：对先兆子痫滋养层合胞化受损的影响

• 发表时间: 2007
• 作者: Nobuzane T;Kudo Y;Nobuzane T;Kudo Y
• 通讯作者: Kudo Y

Effects of menopause and hormone therapy on erythrocyte deformability.

绝经和激素治疗对红细胞变形能力的影响。

• 发表时间: 2009
• 期刊: Menopause 16
• 作者: Sakashita T;Nobuzane T;Miyoshi H;Fujiwara H;Kudo Y
• 通讯作者: Kudo Y

Growth factors and trophoblast differentiation

• DOI: 10.1016/s0143-4004(05)80305-4
• 发表时间: 1992
• 期刊: Placenta
• 影响因子: 3.8
• 作者: D. Evain-Brion

Gene expression profiling of advanced-stage serous ovarian cancers distinguishes novel subclasses and implicates ZEB2 in tumor progression and prognosis

• DOI: 10.1111/j.1349-7006.2009.01204.x
• 发表时间: 2009-08-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Yoshihara, Kosuke;Tajima, Atsushi;Tanaka, Kenichi
• 通讯作者: Tanaka, Kenichi