Study on the mechanisms of human placental trophoblast syncytialisation : implication for the pathogenesis of pre-eclampsia
Study on the mechanisms of human placental trophoblast syncytialisation : implication for the pathogenesis of pre-eclampsia
批准号:
19591895
负责人:
KUDO Yoshiki
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
我们已经证明CD98表面抗原,合胞素,HERV-W(人内源性逆转录病毒-W)的包膜基因,及其受体D型哺乳动物逆转录病毒受体(ASCT2)参与了合体滋养层细胞形成所需的细胞融合过程(细胞滋养层细胞系BeWo在Forsklin处理后细胞内cAMP增加)。
英文摘要
We have demonstrated that CD98 surface antigen, syncytin, an envelope gene of HERV-W (human endogenous retrovirus-W), and its receptor type D mammalian retrovirus receptor (ASCT2) are involved in the process of cell fusion necessary for syncytiotrophoblast formation using a cell model of syncytialisation (the cytotrophoblast cell line BeWo following increased intracellular cAMP by forskolin treatment).
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DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Sakashita T, Kudo Y]
通讯作者:
Kudo Y
Hypoxia suppresses expression of syncytin and cell fusion during syncytialisation of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia
缺氧抑制人胎盘 BeWo 细胞合胞化过程中合胞素的表达和细胞融合:对先兆子痫滋养层合胞化受损的影响
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Nobuzane T, Kudo Y, Nobuzane T, Kudo Y]
通讯作者:
Kudo Y
Effects of menopause and hormone therapy on erythrocyte deformability.
绝经和激素治疗对红细胞变形能力的影响。
DOI:
--
发表时间:
2009
期刊:
Menopause 16
影响因子:
--
作者:
[Sakashita T, Nobuzane T, Miyoshi H, Fujiwara H, Kudo Y]
通讯作者:
Kudo Y
DOI:
10.1016/s0143-4004(05)80305-4
发表时间:
1992
期刊:
Placenta
影响因子:
3.8
作者:
[D. Evain-Brion]
通讯作者:
D. Evain-Brion
DOI:
10.1111/j.1349-7006.2009.01204.x
发表时间:
2009-08-01
期刊:
CANCER SCIENCE
影响因子:
5.7
作者:
[Yoshihara, Kosuke, Tajima, Atsushi, Tanaka, Kenichi]
通讯作者:
Tanaka, Kenichi
共 17 条
Cell and molecular mechanismas of placental syncytialisation: pathogenesis of preeclampsia
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批准号:17K11238
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2017
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负责人:KUDO Yoshiki
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依托单位:
Cell and Molecular mechanisms of placental syncytialisation : implications for the pathogenesis of pre-eclampsia
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批准号:15591752
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:2003
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负责人:KUDO Yoshiki
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依托单位:
海外基金