Development and application of the microarray for the isolation of target genes of transcriptional regulators in periodontal pathogens
Development and application of the microarray for the isolation of target genes of transcriptional regulators in periodontal pathogens
批准号:
19592139
负责人:
NISHIKAWA Kiyoshi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
歯周病原細菌P. gingivalis標準株の全ゲノム配列を搭載した新規マイクロアレイとクロマチン免疫沈降法とを組合わせた解析手法を用い、本菌の主要病原因子FimA線毛の生合成を調節する二成分制御系転写因子FimRのゲノム上の結合配列を特定した。更に線毛非形成株W83では、FimRにリン酸基を供与するセンサータンパク質FimSがATP結合領域の一部を欠失した機能不全型であることをも明らかにした。
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会议论文
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依托单位:
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负责人:NISHIKAWA Kiyoshi
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依托单位:
海外基金