700 MHz NMR Spectrometer

高分辨核磁共振波谱是现代有机化学中最重要、最强大的分析手段。此前在有机化学研究所分析中心的MagRes光谱仪池中用作MagRes核磁共振网络一部分的高场设备是一台500 MHz的核磁共振设备，于1997年投入使用。在用核磁共振表征极少量的样品或难于溶解的有机化合物时，检测灵敏度或光谱分辨率不足，需要具有较高磁场强度的设备。此外，弗莱堡大学有机化学研究所近年来发展迅速，现由6个工作组(3个W3工作组(“MIT LeitungsFunktion”)、2个W3工作组(“Ohne LeitungsFunktion”)、1个初级研究小组组长)组成。因此，为了开展研究工作，需要一个带有Prodigy探头的高频700 MHz设备，即一个氮气冷却的低温探头。这样的设备应该使弗莱堡大学有机化学和制药的有机合成和分析研究小组能够处理以前由于可用的核磁共振设备有限而只能在一些限制下解决的研究项目。为了确保尽可能全面的核磁共振能力，重点是异核核磁共振光谱学(即要测量的不同核)，计划购买一个宽带探头。由于合成或分离高度复杂结构的化合物通常只产生少量物质或--特别是在材料科学领域--大量四元、松弛较差的sp2杂化碳原子，因此核磁共振装置应配备氮气冷却的低温探头，以获得上述特殊项目所需的灵敏度。同时，这种在弗莱堡还没有的高场设备将大大升级核磁共振网络MagRes，因为与带有室温探头的核磁共振光谱仪相比，测量时间减少了10倍，而且即使在样本量最少的情况下，灵敏度也相应地更高。通过购买这样的光谱仪，阿尔伯特-路德维希-弗赖堡大学在结构分析领域的竞争力将在未来十年内在国内和国际上得到保障。

High-resolution NMR spectroscopy is the most important and powerful analytical method in modern organic chemistry. The high-field device previously used as part of the MagRes NMR network in the MagRes spectrometer pool at the Institute of Organic Chemistry's analysis center is a 500 MHz NMR device that was put into operation in 1997. The insufficient detection sensitivity or spectral resolution in characterizing very small sample amounts or poorly soluble organic compounds by NMR requires a device with a higher magnetic field strength. In addition, the Institute of Organic Chemistry at the University of Freiburg has grown significantly in recent years and now consists of 6 working groups (3 x W3 (“mit Leitungsfunktion”), 2 x W3 (“ohne Leitungsfunktion”), 1 x junior research group leader). Therefore, to carry out research work, a high-frequency 700 MHz device with a Prodigy probe, i. e. a nitrogen-cooled cryoprobe head, is needed. Such a device should enable the organic-synthetic and analytical research groups of organic chemistry and pharmacy at the University of Freiburg to tackle research projects that could previously only be addressed with some restrictions due to limited NMR equipment available. In order to ensure the most comprehensive NMR capacity possible with a focus on heteronuclear NMR spectroscopy (i.e. different nuclei to be measured), the purchase of a broadband probe head is planned. Since the synthesis or isolation of chemical compounds with highly complex structures often only produces small amounts of substance or – especially in the field of materials science – a large number of quaternary, poorly relaxing sp2-hybridized carbon atoms, the NMR device should be equipped with a nitrogen-cooled cryoprobe in order to achieve the necessary sensitivity for the special projects mentioned. At the same time, such a high-field device, which is not yet available in Freiburg, will significantly upgrade the NMR network MagRes, since the measurement time is reduced by a factor of 10 compared to an NMR spectrometer with a room temperature probe head and the sensitivity is correspondingly higher even with the smallest amounts of sample. With the purchase of such a spectrometer, the competitiveness of the Albert-Ludwigs-Universität Freiburg in the field of structural analysis will be secured both nationally and internationally within the next decade.