Innovative nano-therapy based on nanocarriers equipped with the ability to circumvent biological barriers

为了实现对胰腺肿瘤等顽固性肿瘤的靶向治疗和核酸分子肿瘤的治疗，我们开发了基于聚合物胶束的新型纳米载体，通过工程功能聚合物材料，可以避免组织和细胞器水平的生物屏障，并对环境变化或物理刺激产生反应。这种纳米载体的有效性已被体外和体内实验证明。

To realize the targeting therapy against intractable tumors such as pancreatic tumors and molecular cancer therapy using nucleic acids, we developed novel nanocarriers based on polymeric micelles, which can avoid biological barriers at the tissue and organelle levels and function responding to environmental changes or physical stimuli, by engineering functional polymeric materials. The usefulness of such nanocarriers has been demonstrated by in vitro and in vivo experiments.