Advanced Control of Stereoselectivity and Chemoselectivity Through Supramolecular Chemistry

通过超分子化学对立体选择性和化学选择性进行高级控制

• 批准号: 20200053
• 负责人: KUMAGAI Naoya
• 金额: $ 19.64万
• 依托单位: 公益財団法人微生物化学研究会・微生物化学研究所 (2010)The University of Tokyo (2008-2009)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20200053/
• 关键词: 触媒設計・反応; 不斉合成; 動的構造多様性触媒; 希土類金属; アミド配位子; 協奏触媒; 適時構造変化; ヘテロキラル集積; 触媒的不斉Conia-ene反応; 水素結合; 適時機能制御型触媒; 不斉触媒; 動的構造多様性; 機能多様性; 4級炭素構築; 不斉Mannich型反応; CDスペクトル; 斉Mannich型反応

Advanced asymmetric catalysts exhibiting trigger-responsive property and self-assembly capability were developed based on structurally flexible amide-based ligands. These smart catalysts allowed us to link the structural dynamics and functional diversity in asymmetric catalysis.

基于结构灵活的酰胺基配体，开发了具有分子响应性和自组装能力的先进不对称催化剂。这些智能催化剂使我们能够将不对称催化中的结构动力学和功能多样性联系起来。

项目成果

Direct catalytic asymmetric aldol reaction of thioamides: a concise asymmetric synthesis of (R)-fluoxetine

• DOI: 10.1016/j.tetasy.2010.04.034
• 发表时间: 2010-07-14
• 期刊: TETRAHEDRON-ASYMMETRY
• 作者: Iwata, Mitsutaka;Yazaki, Ryo;Shibasaki, Masakatsu
• 通讯作者: Shibasaki, Masakatsu

Phospholane,1,1_-(1,2-Ethanediyl)-bis[2,5-diphenyl- (2S,2S_,5S,5S_)1 and Phospholane, 1,1-(1,2-Ethanediyl)-bis[2,5-diphenyl-(2R,2R_,5R,5R_)" ,Encyclopedia of Reagents for Organic Synthesis

磷烷，1,1_-(1,2-乙二基)-双[2,5-二苯基-(2S,2S_,5S,5S_)1 和磷烷，1,1-(1,2-乙二基)-双[2

• 发表时间: 2010
• 作者: 関口敏;飛田良美;千代智子;小原道法;Naoya Kumagai
• 通讯作者: Naoya Kumagai

Asymmetric Synthesis of Isothiazole Entities Through Cu Catalysis : Direct Catalytic Asymmetric Conjugate Addition of Allyl Cyanide to α,β-Unsaturated Thioamides

Cu 催化不对称合成异噻唑实体：烯丙基氰与 α,β-不饱和硫代酰胺的直接催化不对称共轭加成

• 发表时间: 2011
• 期刊: Angew.Chem., Int.Ed. in press
• 作者: Yuka Yanagida;Ryo Yazaki;Naoya Kumagai;Masakatsu Shibasaki
• 通讯作者: Masakatsu Shibasaki

Direct Catalytic Asymmetric Mannich-type Reaction of Thioamides

硫代酰胺的直接催化不对称曼尼希型反应

• 发表时间: 2009
• 期刊: Angew.Chem., Int.Ed. 48(27)
• 作者: Yuta Suzuki;Ryo Yazaki;Naoya Kumagai;Msakatsu Shibasaki
• 通讯作者: Msakatsu Shibasaki

Soft Lewis Acid/Hard Bronsted Base/Hard Lewis Base Catalyzed Highly Atom Economical Construction of Enantioenriched Tertiary Alcohols

软路易斯酸/硬布朗斯台德碱/硬路易斯碱催化高原子经济性构建对映体富集的叔醇

• 发表时间: 2010
• 作者: 嶋田敬介;前川清人;矢崎亮
• 通讯作者: 矢崎亮