Development and Control of Highly Efficient Catalytic Systems for Cross-and Multicomponent-Coupling Reactions

借助于过渡金属催化剂，已经开发了多种用于碳-碳键形成的方法，其使得能够将密集的仲烷基和叔烷基引入有机分子中，引入不饱和烃如炔和二烯的多组分偶联，以及经由非反应性键如C-F、C-O和C-H的裂解的交叉偶联。这些成功的结果表明，阴离子过渡金属物种作为各种合成反应过程中的关键中间体的有效催化反应性。还开发了用于伴随构建碳-碳键和碳-杂原子键的催化反应以及使用电子和/或结构柔性金属络合物的催化反应。

A variety of methods for carbon-carbon bond formation have been developed by the aid of transition metal catalysts, which enabled introduction of congested secondary and tertiary alkyl groups into organic molecules, multi-component coupling incorporating unsaturated hydrocarbons such as alkynes and dienes, and cross coupling via cleavage of unreactive bonds such as C-F, C-O and C-H. These successful results demonstrated potent catalytic reactivities of anionic transition metal species as key intermediates in various synthetic reaction processes. Catalytic reactions for concomitant construct of carbon-carbon bonds and carbon-heteroatom bonds and those using electronically and/or structurally flexible metal complexes were also developed.