Physiological substrates and functions of ABC proteins involved in lipid transport

ATP结合盒（ATP Binding Cassette，ABC）蛋白是一个重要的转运蛋白家族，通过转运脂质发挥重要的生理功能，其功能缺陷与多种疾病有关。本项目通过生物化学/细胞生物学研究、单分子示踪和晶体结构分析等手段，试图揭示它们的生理底物和功能。

Many transporters in the protein family, ATP Binding Cassette (ABC) proteins, have been found to play important physiological roles through transporting lipids, and defects in their functions are related to various diseases. In this project, we tried to reveal theirphysiological substrates and functions by integrating biochemical/cell biological studies, single molecule tracking and crystal structure analyses.