Development of an innovative radiotherapy technologies for the improvement of treatment outcomes of intractable cancers

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Deformable image registration software and a system for evaluating 4-dimensional dose distribution were successfully developed. In addition, three-dimensional unicursal irradiation technique was newly developed, and the usefulness of this technique was confirmed in both pancreatic cancer and skull base tumors. Impacts of movement and deformation in the upper abdominal organs on the dose distribution were estimated for pancreatic cancer. Then, IMRT technique under breath-holding was developed, and phase I doseescalation study for pancreatic cancer was initiated. Clinical studies for both malignant pleural mesothelioma and cervical esophageal cancer were also started.