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The effect of social isolation on the circuit formation in the brain

The effect of social isolation on the circuit formation in the brain
社会隔离对大脑回路形成的影响
批准号:
20300131
负责人:
TAKAHASHI Takuya
金额:
$12.81万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Stressful events during early childhood can have a profound lifelong influence on emotional and cognitive behaviors. However, the mechanisms by which stress affects neonatal brain circuit formation are poorly understood. In this program, we analyzed the effect of neonatal social isolation on the brain circuit formation at the molecular level. We found that neonatal social isolation disrupts experience-dependent synaptic AMPA receptors delivery in the barrel cortex of male rats but not female rats.
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会议论文
経験依存的AMPA受容体シナプス移行
经验依赖性 AMPA 受体突触迁移
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [S.Kunita, K Kato, M Ishida, K Hagiwara, S Kameda, T Ishida, A Takakura, K Goto, F Sugiyama, K Yagami, 高橋琢哉]
通讯作者: 高橋琢哉
Experience driven synaptic delivery of AMPA receptors in vivo.
体验体内 AMPA 受体驱动的突触传递。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Kojima M., Morimoto Y, Nakagawa T., Yanagi, S., Kihara H., Nonaka T, 高橋琢哉]
通讯作者: 高橋琢哉
Sex-specific 24-h profile of extracellular serotonin levels in the medial prefrontal cortex
内侧前额叶皮层细胞外血清素水平的性别特异性 24 小时概况
DOI: 10.1016/j.brainres.2008.12.084
发表时间: 2009
期刊: Brain Research
影响因子: 2.9
作者: [S. Jitsuki, F. Kimura, T. Funabashi, Takuya Takahashi, D. Mitsushima]
通讯作者: D. Mitsushima
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
6
    Biological basis and expanded indications of the rehabilitation-enhancing drug, edonerpic
    • 批准号:
      20H00549
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $29.2万
    • 财政年份:
      2020
    • 负责人:
      TAKAHASHI Takuya
    • 依托单位:
    Analysis of neural circuit formation in the neocortex of socially isolated animals
    • 批准号:
      26290025
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.73万
    • 财政年份:
      2014
    • 负责人:
      TAKAHASHI Takuya
    • 依托单位:
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    • 批准号:
      21510047
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.16万
    • 财政年份:
      2009
    • 负责人:
      TAKAHASHI Takuya
    • 依托单位:
    海外基金