Multi-scale simulation model of cardiomyocyte based on the micromechanical measurement of subcellular structure

基于亚细胞结构微力学测量的心肌细胞多尺度仿真模型

• 批准号: 20300152
• 负责人: SUGIURA Seiryo
• 金额: $ 11.9万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20300152/
• 关键词: 心筋細胞; 微小計測; 細胞シミュレーション

In this study, first, we developed novel experimental techniques to evaluate the subcellular structures and properties of ventricular myocytes. Based on these findings, we, then, created a 3D finite element of myocyte in which cardiac electrophysiology, contraction, and metabolism are integrated with detailed subcellular structures. The model successfully reproduced and provided the distribution of ions and metabolites beyond the limit of current experimental observations thus proved to be a useful tool for the study of cardiac pathophysiology.

在这项研究中，首先，我们开发了新的实验技术来评估心室肌细胞的亚细胞结构和特性。基于这些发现，我们创建了心肌细胞的三维有限元，其中心脏电生理、收缩和代谢与详细的亚细胞结构相结合。该模型成功地再现并提供了超出目前实验观察极限的离子和代谢物分布，从而被证明是心脏病理生理学研究的有用工具。

项目成果

Micromechanical measurement by laser optical tweezer revealed anisotropy in the stiffness of rat ventricular myocytes

激光光镊微机械测量揭示大鼠心室肌细胞硬度的各向异性

• 发表时间: 2010
• 作者: Masumoto S;Fukano H;Iwanami S;Yamashita H;Hisada T;Sugiura S
• 通讯作者: Sugiura S

冠循環と心筋収縮の関係へのモデルによるアプローチ,A simulation studyon the effect of cardiac contraction on the coronary circulation

基于模型的冠状循环与心肌收缩关系的方法，心脏收缩对冠状循环影响的模拟研究

• 发表时间: 2008
• 作者: 杉浦清了;岡田純一;鷲尾巧;渡邊浩志;久田俊明
• 通讯作者: 久田俊明

Ut Heart, a Multi-scale, Multi-physics Simulator

Ut Heart，多尺度、多物理场模拟器

• 发表时间: 2010
• 作者: Seiryo Sugiura;Takumi Washio;Jun-ichi Okada;Hiroshi Watanabe;Toshiaki Hisada
• 通讯作者: Toshiaki Hisada

Induction of Ca^<2+> spark by mechanical stress is dependent on the direction of applied stresss in the rat ventricular myocytes

机械应力诱导 Ca^<2> 火花取决于大鼠心室肌细胞中施加应力的方向

• 发表时间: 2009
• 作者: Fukano H;Masumoto S;Iwanami S;Yamashita H;Hisada T;Sugiura S
• 通讯作者: Sugiura S

Multi-scale approach for the understanding of cardiac function Arrhythmia and muscle contraction

了解心脏功能心律失常和肌肉收缩的多尺度方法

• 发表时间: 2009
• 作者: Fukano H;Masumoto S;Iwanami S;Yamashita H;Hisada T;Sugiura S;Hana Fukano;Seiryo Sugiura(invited)
• 通讯作者: Seiryo Sugiura(invited)