Multi-scale simulation model of cardiomyocyte based on the micromechanical measurement of subcellular structure

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In this study, first, we developed novel experimental techniques to evaluate the subcellular structures and properties of ventricular myocytes. Based on these findings, we, then, created a 3D finite element of myocyte in which cardiac electrophysiology, contraction, and metabolism are integrated with detailed subcellular structures. The model successfully reproduced and provided the distribution of ions and metabolites beyond the limit of current experimental observations thus proved to be a useful tool for the study of cardiac pathophysiology.