Development of On-Chip Cell Manipulation System Capable of Massively Parallel Patterning of Single Cells

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A good understanding of extensive cellular knowledge is a prerequisite to enabling innovative technological advances in the field of highly-advanced medical treatment and drug discovery, because biological cells are the structural and functional units of all known living organisms. Cell patterning that enables in vitro patterned cell culture is one of the key technologies for addressing fundamental issues related to single cell analysis and cellular network analysis. Therefore, this research focused on the development of a novel cell patterning technique based on a micromanipulator array integrated with microvalves capable of massively parallel trapping and manipulation of single living cells.