Analysis of myocardial molecular motor dynamics and excitation contraction coupling

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We have studied cardiovascular physiology, especially in myocardial excitation contraction coupling. We have observed and studied the cardiac contractile performance and have made mechanical and energetical analysis. We have reported that load dependent increase in cardiac contractile performance depends on the actin-myosin interaction but not on alteration of the intramyocardial Ca^<2+> dynamics. The X-ray diffraction, provided by the SPring-8 synchrotron radiation facility, is the most useful experimental technique to observe the actin-myosin interaction in the beating whole heart. In this study, we established a method to observe actin-myosin interaction in the rat beating whole heart and analyzed it in the pathophysiological models.