Molecular mechanism that keep stem cells as a quiescent condition

保持干细胞处于静止状态的分子机制

• 批准号: 20370089
• 负责人: OHTA Kunimasa
• 金额: $ 12.98万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20370089/
• 关键词: 幹細胞; 再生医学; Tsukushi; Wnt

We have reported that Tsukushi, which belongs to small leucine-rich proteoglycan family, functions as a novel Wnt signaling inhibitor at the extracellular region. We found that Tsukushi is expressed in the ciliary body in the eye, the subventricular zone in the lateral ventricles, the dentate gyrus in the hippocampus. In the Tsukushi KO mouse brain, the cell proliferation in the ciliary body and the subventricular zone were increase compared to wild type brain. Our data suggested that Tsukushi functions as a niche molecule for the regulation of neural stem/progenitor cells.

我们已经报道，Tsukushi属于富含亮氨酸的小蛋白多糖家族，在胞外区作为一种新的Wnt信号抑制因子发挥作用。我们发现Tsukushi在眼睛的睫状体、侧脑室的脑室下区和海马齿状回都有表达。在Tsukushi KO小鼠脑中，睫状体和脑室下区的细胞增殖比野生型脑增加。我们的数据表明，Tsukushi作为一种利基分子来调节神经干细胞/祖细胞。

项目成果

Tsukushi is a novel Wnt signaling inhibitor involved in ciliary body formation in mammalian eye by regulating retinal progenitor cells prolieration

Tsukushi 是一种新型 Wnt 信号抑制剂，通过调节视网膜祖细胞增殖参与哺乳动物眼睫状体的形成

• 发表时间: 2009
• 作者: 平郁子;ら;原田尚子;本間光一;Kenji Tomita;Koichi Kosaka;Takeshi Kawauchi;Kazunori Nakajima;Shinji Sasaki;Shigealci Kanatani;Kenji Tomita;Ken-ichiro Kubo;Koji Oishi;Yoshiaki V. Nishimura;Kashiko Tachikawa;Yuko Gonda;Yoshiaki V. Nishimura;Ken-ichiro Kubo;Toshitaka Nabeshima;Joseph W. Yip;Atsushi Kamiya;Yuko Gonda;Takahiro Okubo;Koji Oishi;Yoshiaki Nishimura;Koji Oishi;仲嶋一範;林田桃子;Shahidul. MD. Islam;太田訓正;太田訓正;太田訓正;太田訓正;太田訓正;太田訓正
• 通讯作者: 太田訓正

Tsukushiによる網膜幹細胞の未分化性維持機構

Tsukushi维持视网膜干细胞未分化状态的机制

• 发表时间: 2008
• 作者: 平郁子;ら;原田尚子;本間光一;Kenji Tomita;Koichi Kosaka;Takeshi Kawauchi;Kazunori Nakajima;Shinji Sasaki;Shigealci Kanatani;Kenji Tomita;Ken-ichiro Kubo;Koji Oishi;Yoshiaki V. Nishimura;Kashiko Tachikawa;Yuko Gonda;Yoshiaki V. Nishimura;Ken-ichiro Kubo;Toshitaka Nabeshima;Joseph W. Yip;Atsushi Kamiya;Yuko Gonda;Takahiro Okubo;Koji Oishi;Yoshiaki Nishimura;Koji Oishi;仲嶋一範;林田桃子;Shahidul. MD. Islam;太田訓正;太田訓正;太田訓正;太田訓正;太田訓正;太田訓正;太田訓正;太田訓正;太田訓正;太田訓正
• 通讯作者: 太田訓正

Tsukushiによる網膜幹細胞/前駆細胞の未分化性維持機構

Tsukushi维持视网膜干细胞/祖细胞未分化状态的机制

• 发表时间: 2009
• 作者: 平郁子;ら;原田尚子;本間光一;Kenji Tomita;Koichi Kosaka;Takeshi Kawauchi;Kazunori Nakajima;Shinji Sasaki;Shigealci Kanatani;Kenji Tomita;Ken-ichiro Kubo;Koji Oishi;Yoshiaki V. Nishimura;Kashiko Tachikawa;Yuko Gonda;Yoshiaki V. Nishimura;Ken-ichiro Kubo;Toshitaka Nabeshima;Joseph W. Yip;Atsushi Kamiya;Yuko Gonda;Takahiro Okubo;Koji Oishi;Yoshiaki Nishimura;Koji Oishi;仲嶋一範;林田桃子;Shahidul. MD. Islam;太田訓正
• 通讯作者: 太田訓正

Tsukushi is Feizzled 4 ligand that regulates neuronal stem cells proliferation

Tsukushi 是调节神经元干细胞增殖的 Feizzled 4 配体

• 发表时间: 2009
• 作者: 平郁子;ら;原田尚子;本間光一;Kenji Tomita;Koichi Kosaka;Takeshi Kawauchi;Kazunori Nakajima;Shinji Sasaki;Shigealci Kanatani;Kenji Tomita;Ken-ichiro Kubo;Koji Oishi;Yoshiaki V. Nishimura;Kashiko Tachikawa;Yuko Gonda;Yoshiaki V. Nishimura;Ken-ichiro Kubo;Toshitaka Nabeshima;Joseph W. Yip;Atsushi Kamiya;Yuko Gonda;Takahiro Okubo;Koji Oishi;Yoshiaki Nishimura;Koji Oishi;仲嶋一範;林田桃子;Shahidul. MD. Islam;太田訓正;太田訓正;太田訓正
• 通讯作者: 太田訓正

Tsukushiは網膜幹/前駆細胞の増殖を制御するWntシグナル阻害因子である

Tsukushi 是一种 Wnt 信号抑制剂，可控制视网膜干/祖细胞的增殖

• 发表时间: 2008
• 作者: 平郁子;ら;原田尚子;本間光一;Kenji Tomita;Koichi Kosaka;Takeshi Kawauchi;Kazunori Nakajima;Shinji Sasaki;Shigealci Kanatani;Kenji Tomita;Ken-ichiro Kubo;Koji Oishi;Yoshiaki V. Nishimura;Kashiko Tachikawa;Yuko Gonda;Yoshiaki V. Nishimura;Ken-ichiro Kubo;Toshitaka Nabeshima;Joseph W. Yip;Atsushi Kamiya;Yuko Gonda;Takahiro Okubo;Koji Oishi;Yoshiaki Nishimura;Koji Oishi;仲嶋一範;林田桃子;Shahidul. MD. Islam;太田訓正;太田訓正;太田訓正;太田訓正;太田訓正;太田訓正;太田訓正;太田訓正;太田訓正
• 通讯作者: 太田訓正