Molecular mechanisms of protein synthesis shutdown in insect cells infected with nucleopolyhedrovirus

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The molecular basis for the global protein synthesis shutdown in Bombyx mori BM-N cells caused by several nucleopolyhedroviruses (NPVs) infections is not well known. In this study, we showed that the RNA in BM-N cells was degraded quickly after abortive infection of the cells by various NPVs. In contrast, the RNA degradation was not induced by Bombyx mori NPV infection which results in productive infection in the cells. These results indicate that a viral factor and/or its function induce the degradation of RNA, which causes global protein synthesis shutdown in BM-N cells.