Time and spatial regulation of the embryo implantation at fetomaternal interface ; the resolution of habitual and spontaneous abortion.

胚胎在母胎界面着床的时间和空间调控；

• 批准号: 20380161
• 负责人: HONDO Eiichi
• 金额: $ 12.15万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20380161/
• 关键词: LIF,胚着床; 脱落膜化; スペーシング; 胚着床; 白血病阻止因子; Agrin-アセチルコリン系; 着床阻害試験; オルファクトメジン; マウス; 発現プロファイル

This study aimed to clarify the mechanism of embryo implantation in mice. The process of embryo implantation is divided into 2 portions ; spacing of the embryo before attachment of the embryo to the surface of the endometrium, and remodeling of the endometrium after attachment. In addition to these analysis of molecular networks regulating embryo implantation, development of the technique which disrupt the molecular network discovered, was performed. In the study of embryo spacing, the predicted regions where the embryo attaches, were already determined before the embryo descended from the oviduct to the uterine horn. Also, it was revealed about remodeling of the endometrium that LIF regulates the progesterone pathway, and Agrin-acetylcholine pathway, which is indispensable for the function at the neuro-muscular junction. Finary, very easy method to disrupt embryo implantation was invented in this study. This study must promote rapid and wide development of investigation in embryo implantation.

本研究旨在阐明小鼠胚胎着床的机制。胚胎着床的过程分为两个部分：胚胎附着到子宫内膜表面之前的胚胎间隔，以及附着后子宫内膜的重塑。除了这些调控胚胎植入的分子网络的分析之外，还进行了破坏所发现的分子网络的技术的开发。在胚胎间隔的研究中，在胚胎从输卵管下降到子宫角之前，已经确定了胚胎附着的预测区域。此外，关于子宫内膜的重塑，揭示了LIF调节孕酮途径和Agrin-乙酰胆碱途径，其对于神经肌肉接头处的功能是不可或缺的。最后，本研究还发明了一种非常简单的方法来破坏胚胎着床。这一研究必将促进胚胎着床研究的快速、广泛发展。

项目成果

Reproductive Performance in Diabetes Mice with a Special Reference to Uterine Natural Killer Cells and Placental Growth Factor

• DOI: 10.1292/jvms.71.519
• 发表时间: 2009-04-01
• 期刊: JOURNAL OF VETERINARY MEDICAL SCIENCE
• 影响因子: 1.2
• 作者: Phichitrasilp, Thanmaporn;Hondo, Eiichi;Kiso, Yasuo
• 通讯作者: Kiso, Yasuo

ホームページ等。

主页等

Spacing of the embryo in the uterus is disrupted by the supine position of the body during the peri-implantation period in mice.

小鼠在植入期间，身体的仰卧位置会扰乱子宫中胚胎的间距。

• 发表时间: 2010
• 期刊: Reprod Dev. 56(2)
• 作者: Sugiyama M;Terakawa J;Khan H;Wakitani S;Choi EK;Kiso Y;Hondo E.
• 通讯作者: Hondo E.

タイ国におけるオオコウモリの調査

泰国果蝠研究

• 发表时间: 2009
• 期刊: 山口県獣医師会雑誌 (In press)
• 作者: Fernand Fagutao;Takashi Koyama;Hidehiro Kondo;Takashi Aoki;Ikuo Hirono;本道栄一
• 通讯作者: 本道栄一

Spontaneous endometrial hyperplasia in the uteri of IL-2 receptor beta-chain transgenic mice

IL-2受体β链转基因小鼠子宫内膜自发性增生

• 发表时间: 2009
• 期刊: J Reprod Dev. 55(3)
• 作者: Kusakabe K;Kiso Y;Hondo E;Takeshita A;Kato K;Okada T;Shibata MA;Otsuki Y
• 通讯作者: Otsuki Y