Time and spatial regulation of the embryo implantation at fetomaternal interface ; the resolution of habitual and spontaneous abortion.

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This study aimed to clarify the mechanism of embryo implantation in mice. The process of embryo implantation is divided into 2 portions ; spacing of the embryo before attachment of the embryo to the surface of the endometrium, and remodeling of the endometrium after attachment. In addition to these analysis of molecular networks regulating embryo implantation, development of the technique which disrupt the molecular network discovered, was performed. In the study of embryo spacing, the predicted regions where the embryo attaches, were already determined before the embryo descended from the oviduct to the uterine horn. Also, it was revealed about remodeling of the endometrium that LIF regulates the progesterone pathway, and Agrin-acetylcholine pathway, which is indispensable for the function at the neuro-muscular junction. Finary, very easy method to disrupt embryo implantation was invented in this study. This study must promote rapid and wide development of investigation in embryo implantation.