Does low-gravity environment change the genome and morphology in the living organisms?

本研究旨在通过模拟地球上0.58g的低重力环境，阐明低重力对脊椎动物的影响。ICR小鼠暴露于低重力环境2周后，实验组（低重力）和对照组小鼠的体重存在差异。与对照组相比，实验组小鼠中的它们倾向于减少。采用染色质免疫沉淀法（ChIP）比较两组睾丸基因组DNA甲基化模式，然后进行下一代测序。测序结果表明，重叠群序列与18个基因内部或附近的重叠群序列相对应。其中一些基因被预测与阿尔茨海默病有关。

This study aimed to clarify the effect of low-gravity on the vertebrates by mimicking its environment on the earth with realizing 0.58g. After the ICR mice were exposed to the low-gravity environment for 2 weeks, the weights of mice differed between the experimental group (low-gravity) and the control. They tended to decrease in the mice of the experimental group compared to the control. The methylation patterns of testicular genomic DNA in both groups were compared using chromatin immunoprecipitation method (ChIP), followed by the next generation sequencing. The contig-sequences by the sequencing corresponded to those inside or nearby 18 genes. Some of these genes are predicted Alzheimer related.