Study of molecular mechanism of the ER quality control in plants

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If proteins with abnormal structures accumulate in the intracellular compartment called the endoplasmic reticulum (ER), such condition is transmitted to the nucleus causing activation of genes for chaperones that assist the correct folding of proteins. We found that a sensor protein IRE1 localizing on the ER membrane is involved in cytoplasmic splicing as the first report of cytoplasmic splicing in plants. It was considered that a membrane bound transcription factor bZIP60 was converted to active form losing its transmembrane domain by the splicing and translocated to the nucleus activating target genes.