Organic synthesis using cationic species under non-acidic conditions

研究了羟基保护基团（MOM-, MEM-， SEM-和bm -醚）的高效脱保护和MOM-醚向其他缩醛型保护基团的一锅转化。一些亲核试剂通过阳离子盐中间体被成功地引入到2-脱氧糖的端粒位置。通过对吡啶型成盐碱的研究，发展了亲核碳取代阳离子盐中间体的研究。利用moma -醚的盐与有机酸盐反应，开发了一种制备拥挤醚的高效方法，解决了以往方法难以合成的问题。

Efficient deprotection of acetal-type protective groups(MOM-, MEM-, SEM-, and BOM-ether) of hydroxyl function and one-pot transformation of MOM-ethers to other acetal-type protective groups have been developed. Introduction of some nucleophiles to the anomeric position of 2-deoxysugars via cationic salt intermediates has been succeeded. Nucleophilic substitution of carbon nucleopohiles to cationic salt intermediate has been developed by studying the kind of pyridine-type base for forming salt. Efficient preparation method of crowded ethers, which are hard to be synthesized by previous methods, has been developed by the reaction of the salts, from MOM-ethers, and organocuprate reagents.